A utilidade do biomarcador presepsina no diagnóstico e prognóstico da Sepse e do choque séptico
DOI:
https://doi.org/10.34119/bjhrv6n1-308Keywords:
diagnóstico, presepsina, prognóstico, sepse, choque sépticoAbstract
Objetivo: Determinar a utilidade do biomarcador pré-seleção no diagnóstico e prognóstico da sepse e do choque séptico. Método: O tipo de estudo a ser realizado é uma revisão de literatura, que será composta de artigos em inglês e espanhol contendo informações relevantes para a revisão, a seleção dos artigos será feita através das bases de dados: PubMed, Sciendirect, Scopus, Taylor & Francis e Web of Science; a pesquisa será realizada com os termos do Medical Subject Headings (MesH) da Biblioteca Nacional de Medicina e descritores em ciências da saúde (DeCS) da Bireme; para a escolha dos estudos serão aplicados critérios de inclusão e exclusão, sendo dos mais importantes que estejam dentro do período 2018-2022. Resultados: Concluiu-se que a presepsina pode ser usada como um biomarcador capaz de diagnosticar precocemente sepse e choque séptico, pois os valores séricos são mais altos dependendo da gravidade da condição. Além disso, é importante notar que com relação às sensibilidades e especificidades, foram encontradas curvas ROC entre 0,688-1 em adultos, e 0,887-099 em adultos. Conclusão: A presepsina é muito útil no diagnóstico e prognóstico de pacientes com sepse e choque séptico, pois seus valores séricos permitiram a diferenciação entre sepse e choque séptico. Também é importante destacar seu valor prognóstico, onde foi possível correlacionar que quanto maiores os níveis de presepsina, maior a porcentagem de não sobreviventes, enquanto que quanto menores os valores de presepsina, maior a taxa de sobrevivência.
References
Abdelshafey, E. E., Nasa, P., Elgohary, A. E., Khalil, M. F., Rashwan, M. A., Ghezala, H. B., & Tayar, A. A. (2021). Role of Presepsin for the Diagnosis of Sepsis and ICU Mortality: A Prospective Controlled Study. Indian Journal of Critical Care Medicine : Peer-Reviewed, Official Publication of Indian Society of Critical Care Medicine, 25(2), 153–157. https://doi.org/10.5005/JP-JOURNALS-10071-23715
Aliu-Bejta, A., Atelj, A., Kurshumliu, M., Dreshaj, S., & Baršić, B. (2020). Presepsin values as markers of severity of sepsis. International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases, 95, 1–7. https://doi.org/10.1016/J.IJID.2020.03.057
Alper Tahmaz, Filiz Kizilates, & Nefise Oztoprak. (2021). Investigation of Plasma Presepsin (sCD14-ST) Levels in Sepsis. Revista Mediterránea de Microbios Infecciosos y Antimicrobianos. https://mjima.org/uploads/pdf/pdf_308.pdf
Azim, A. (2021). Presepsin: A Promising Biomarker for Sepsis. Indian Journal of Critical Care Medicine : Peer-Reviewed, Official Publication of Indian Society of Critical Care Medicine, 25(2), 117–118. https://doi.org/10.5005/JP-JOURNALS-10071-23741
Camargo Rubio, R. D., Fernández Chica, D., Thomae, R., Alcocer Olaciregui, A., & Vargas Moranth, R. (2018). Diagnóstico y pronóstico de sepsis con presepsina en el Departamento de Urgencias. Acta Colombiana de Cuidado Intensivo, 18(2), 92–99. https://doi.org/10.1016/J.ACCI.2018.02.005
Camas y Egresos Hospitalarios |. (n.d.). Retrieved September 25, 2022, from https://www.ecuadorencifras.gob.ec/camas-y-egresos-hospitalarios/
Candel González, F. J., Borges Sá, M., Belda, S., Bou, G., del Pozo, J. L., Estrada, O., Ferrer, R., del Castillo, J. G., Julián-Jiménez, A., Martín-Loeches, I., Maseda, E., Matesanz, M., Ramírez, P., Ramos, J. T., Rello, J., Suberviola, B., de la Rica, A. S., & Vidal, P. (2018). Current aspects in sepsis approach. Turning things around. Revista Española de Quimioterapia, 31(4), 298. /pmc/articles/PMC6172679/
Chen, M., & Zhu, Y. (2020). Utility of sTREM-1 and presepsin (sCD14-ST) as diagnostic and prognostic markers of sepsis. Clinical Laboratory, 66(4), 495–501. https://doi.org/10.7754/CLIN.LAB.2019.190508
Deǧirmencioǧlu, H., Ozer Bekmez, B., Derme, T., Öncel, M. Y., Canpolat, F. E., & Tayman, C. (2019). Presepsin and fetuin-A dyad for the diagnosis of proven sepsis in preterm neonates. BMC Infectious Diseases, 19(1). https://doi.org/10.1186/S12879-019-4316-5
Drăgoescu, A. N., Pădureanu, V., Stănculescu, A. D., Chiuțu, L. C., Florescu, D. N., Gheonea, I. A., Pădureanu, R., Stepan, A., Streba, C. T., Drocaș, A. I., Ciocâlteu-Ionescu, A. M., Șurlin, V. M., & Drăgoescu, O. P. (2021). Presepsin as a Potential Prognostic Marker for Sepsis According to Actual Practice Guidelines. Journal of Personalized Medicine, 11(1), 1–9. https://doi.org/10.3390/JPM11010002
el Said, A. M., Fayed, A. M., & El-Reweny, E. M. (2020). Comparative study between complete blood picture indices and presepsin as early prognostic markers in septic shock patients. Https://Doi-Org.Vpn.Ucacue.Edu.Ec/10.1080/11101849.2020.1789403, 36(1), 118–125. https://doi.org/10.1080/11101849.2020.1789403
Galliera, E., Massaccesi, L., de Vecchi, E., Banfi, G., & Romanelli, M. M. C. (2019). Clinical application of presepsin as diagnostic biomarker of infection: overview and updates. Clinical Chemistry and Laboratory Medicine, 58(1). https://doi.org/10.1515/CCLM-2019-0643
Hashem, H. E., Abdel Halim, R. M., el Masry, S. A., Mokhtar, A. M., & Abdelaal, N. M. (2020). The Utility of Neutrophil CD64 and Presepsin as Diagnostic, Prognostic, and Monitoring Biomarkers in Neonatal Sepsis. International Journal of Microbiology, 2020. https://doi.org/10.1155/2020/8814892
Hassan, E. A., Rehim, A. S. A., Ahmed, A. O., Abdullahtif, H., & Attia, A. (2019). Clinical Value of Presepsin in Comparison to hsCRP as a Monitoring and Early Prognostic Marker for Sepsis in Critically Ill Patients. Medicina (Kaunas, Lithuania), 55(2). https://doi.org/10.3390/MEDICINA55020036
Hincu, M. A., Zonda, G. I., Stanciu, G. D., Nemescu, D., & Paduraru, L. (2020). Relevance of Biomarkers Currently in Use or Research for Practical Diagnosis Approach of Neonatal Early-Onset Sepsis. Children, 7(12). https://doi.org/10.3390/CHILDREN7120309
Hung, S. K., Lan, H. M., Han, S. T., Wu, C. C., & Chen, K. F. (2020). Current Evidence and Limitation of Biomarkers for Detecting Sepsis and Systemic Infection. Biomedicines, 8(11), 1–15. https://doi.org/10.3390/BIOMEDICINES8110494
Jereb, M., Mavric, M., Skvarc, M., Drobnic, A., Dolenc, S., Strunjas, N. P., Luksic, B., & Kmet, N. G. (2019). Usefulness of presepsin as diagnostic and prognostic marker of sepsis in daily clinical practice. Journal of Infection in Developing Countries, 13(11), 1038–1044. https://doi.org/10.3855/JIDC.11764
Khashaba, M. A., Abdelal, I. F., Abd El Rahman, S. M., & Abdel Rahman, M. H. (2022). Sequential estimation of the national early warning score-2 and SERUM PRESEPSIN might discriminate sepsis patients who were vulnerable to death in surgical ICU. Https://Doi-Org.Vpn.Ucacue.Edu.Ec/10.1080/11101849.2022.2125249, 38(1), 535–541. https://doi.org/10.1080/11101849.2022.2125249
Koh, J. S., Kim, Y. J., Kang, D. H., Lee, J. E., & Lee, S.-I. (2021). Usefulness of presepsin in predicting the prognosis of patients with sepsis or septic shock: a retrospective cohort study. Yeungnam University Journal of Medicine, 38(4), 318–325. https://doi.org/10.12701/YUJM.2021.01018
Kondo, Y., Umemura, Y., Hayashida, K., Hara, Y., Aihara, M., & Yamakawa, K. (2019). Diagnostic value of procalcitonin and presepsin for sepsis in critically ill adult patients: a systematic review and meta-analysis. Journal of Intensive Care, 7(1). https://doi.org/10.1186/S40560-019-0374-4
Lee, J., Kim, S., Kim, K. H., Jeong, N. R., Kim, S. C., & Oh, E. J. (2021). The Association between Dynamic Changes in Serum Presepsin Levels and Mortality in Immunocompromised Patients with Sepsis: A Prospective Cohort Study. Diagnostics (Basel, Switzerland), 11(1). https://doi.org/10.3390/DIAGNOSTICS11010060
Lee, S., Song, J., Park, D. W., Seok, H., Ahn, S., Kim, J., Park, J., Cho, H. jin, & Moon, S. (2022). Diagnostic and prognostic value of presepsin and procalcitonin in non-infectious organ failure, sepsis, and septic shock: a prospective observational study according to the Sepsis-3 definitions. BMC Infectious Diseases, 22(1), 1–12. https://doi.org/10.1186/S12879-021-07012-8/TABLES/5
Lu, B., Zhang, Y., Li, C., Liu, C., Yao, Y., Su, M., & Shou, S. (2018). The utility of presepsin in diagnosis and risk stratification for the emergency patients with sepsis. The American Journal of Emergency Medicine, 36(8), 1341–1345. https://doi.org/10.1016/J.AJEM.2017.12.038
Maddaloni, C., de Rose, D. U., Santisi, A., Martini, L., Caoci, S., Bersani, I., Ronchetti, M. P., & Auriti, C. (2021). The Emerging Role of Presepsin (P-SEP) in the Diagnosis of Sepsis in the Critically Ill Infant: A Literature Review. International Journal of Molecular Sciences, 22(22). https://doi.org/10.3390/IJMS222212154
Memar, M. Y., & Baghi, H. B. (2019). Presepsin: A promising biomarker for the detection of bacterial infections. Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie, 111, 649–656. https://doi.org/10.1016/J.BIOPHA.2018.12.124
Mierzchała-Pasierb, M., & Lipinska-Gediga, M. (2019). Sepsis diagnosis and monitoring – procalcitonin as standard, but what next? Anaesthesiology Intensive Therapy, 51(4), 299–305. https://doi.org/10.5114/AIT.2019.88104
Mwesigye, P., Rizwan, F., Alassaf, N., & Khan, R. (2021). The Role and Validity of Diagnostic Biomarkers in Late-Onset Neonatal Sepsis. Cureus, 13(8). https://doi.org/10.7759/CUREUS.17065
Parri, N., Trippella, G., Lisi, C., de Martino, M., Galli, L., & Chiappini, E. (2019). Accuracy of presepsin in neonatal sepsis: systematic review and meta-analysis. Expert Review of Anti-Infective Therapy, 17(4), 223–232. https://doi.org/10.1080/14787210.2019.1584037
Pietrasanta, C., Ronchi, A., Vener, C., Poggi, C., Ballerini, C., Testa, L., Colombo, R. M., Spada, E., Dani, C., Mosca, F., & Pugni, L. (2021). Presepsin (Soluble cd14 subtype) as an early marker of neonatal sepsis and septic shock: A prospective diagnostic trial. Antibiotics, 10(5). https://doi.org/10.3390/ANTIBIOTICS10050580/S1
Ruan, L., Chen, G. Y., Liu, Z., Zhao, Y., Xu, G. Y., Li, S. F., Li, C. N., Chen, L. S., & Tao, Z. (2018). The combination of procalcitonin and C-reactive protein or presepsin alone improves the accuracy of diagnosis of neonatal sepsis: A meta-analysis and systematic review. Critical Care, 22(1), 1–9. https://doi.org/10.1186/S13054-018-2236-1/FIGURES/5
Salomão, R., Ferreira, B. L., Salomão, M. C., Santos, S. S., Azevedo, L. C. P., & Brunialti, M. K. C. (2019). Sepsis: evolving concepts and challenges. Brazilian Journal of Medical and Biological Research, 52(4). https://doi.org/10.1590/1414-431X20198595
van Maldeghem, I., Nusman, C. M., & Visser, D. H. (2019). Soluble CD14 subtype (sCD14-ST) as biomarker in neonatal early-onset sepsis and late-onset sepsis: A systematic review and meta-analysis. BMC Immunology, 20(1), 1–11. https://doi.org/10.1186/S12865-019-0298-8/FIGURES/7
Velissaris, D., Zareifopoulos, N., Karamouzos, V., Karanikolas, E., Pierrakos, C., Koniari, I., & Karanikolas, M. (2021). Presepsin as a Diagnostic and Prognostic Biomarker in Sepsis. Cureus, 13(5). https://doi.org/10.7759/CUREUS.15019
Venugopalan, D. P., Pillai, G., & Krishnan, S. (2019). Diagnostic Value and Prognostic Use of Presepsin Versus Procalcitonin in Sepsis. Cureus, 11(7). https://doi.org/10.7759/CUREUS.5151
Wen, M. Y., Huang, L. Q., Yang, F., Ye, J. K., Cai, G. X., Li, X. S., Ding, H. G., & Zeng, H. K. (2019). Presepsin level in predicting patients’ in-hospital mortality from sepsis under sepsis-3 criteria. Therapeutics and Clinical Risk Management, 15, 733–739. https://doi.org/10.2147/TCRM.S209710
Yamamoto, T., Nishimura, T., Kaga, S., Uchida, K., Tachibana, Y., Esaki, M., Fukushima, W., Kondo, K., & Mizobata, Y. (2019). Diagnostic accuracy of presepsin for sepsis by the new Sepsis-3 definitions. The American Journal of Emergency Medicine, 37(10), 1936–1941. https://doi.org/10.1016/J.AJEM.2019.01.025
Yang, H. S., Hur, M., Yi, A., Kim, H., Lee, S., & Kim, S. N. (2018). Prognostic value of presepsin in adult patients with sepsis: Systematic review and meta-analysis. PLOS ONE, 13(1), e0191486. https://doi.org/10.1371/JOURNAL.PONE.0191486
Yoon, S. H., Kim, E. H., Kim, H. Y., & Ahn, J. G. (2019). Presepsin as a diagnostic marker of sepsis in children and adolescents: A systemic review and meta-analysis. BMC Infectious Diseases, 19(1), 1–11. https://doi.org/10.1186/S12879-019-4397-1/TABLES/3
Zhu, Y., Li, X., Guo, P., Chen, Y., Li, J., & Tao, T. (2019). The accuracy assessment of presepsin (sCD14-ST) for mortality prediction in adult patients with sepsis and a head-to-head comparison to PCT: a meta-analysis. Therapeutics and Clinical Risk Management, 15, 741. https://doi.org/10.2147/TCRM.S198735
