Ação da Covid-19 na enzima conversora de angiotensina 2 e consequências renais
DOI:
https://doi.org/10.34119/bjhrv6n1-135Keywords:
Covid-19, SARS-CoV-2, lesão renalAbstract
Objetivo-. Este estudo teve o objetivo de demonstrar como o vírus SARS-CoV-2 pode causar problemas ao sistema renal. Métodos - Trata-se de uma revisão da literatura, onde foram coletados artigos visando descrever a forma pelo qual o vírus SARS-CoV-2 causas danos ao sistema renal. Resultados- Foi relato que a ocorrência de danos renais como efeito adverso da Covid-19, está relacionada com a forma utilizada pelo vírus SARS-CoV-2 para interagir com as células do hospedeiro, que se dá por meio da ligação com a Enzima Conversora de Angiotensina 2, o que causa desregulação do sistema angiotensina aldosterona, de modo que, foi demonstrado que a insuficiência renal aguda é o principal dano causado aos rins, sendo considerada então, uma condição que está interligada com o aumento de óbitos em virtude de casos graves da Covid-19 e comprometimento renal. Conclusão- O presente estudo constatou que, o comprometimento renal é considerado como um dano secundário em casos graves da Covid-19, que ocorre devido a ligação do vírus SARS-CoV-2 com a Enzima Conversora de Angiotensina 2. Gerando então a interferência na regulação do sistema renina angiotensina aldosterona, que é um componente essencial para o controle do sistema renal, o que causou o aumento do número de casos de insuficiência renal aguda devido a permanecia a longo prazo da Covid-19.
References
ALFANO, G.; GUARALDI, G.; FONTANA, F.; et al. The Role of the Renin-Angiotensin System in Severe Acute Respiratory Syndrome-CoV-2 Infection. Blood Purification, v. 50, n. 2, p. 263–67, 2021. The Role of the Renin-Angiotensin System in Severe Acute Respiratory Syndrome-CoV-2 Infection - PMC (nih.gov)
BEHZAD, S.; AGHAGHAZVINI, L.; RADMARD, A. R.; GHOLAMREZANEZHAD, A. Extrapulmonary manifestations of COVID-19: Radiologic and clinical overview. Clinical Imaging, v. 66, n. April, p. 35–41, 2020. Extrapulmonary manifestations of COVID-19: Radiologic and clinical overview - PMC (nih.gov)
BRUCHFELD, A. The COVID-19 pandemic: consequences for nephrology. Nature Reviews Nephrology, v. 17, n. 2, p. 81–2, 2021. The COVID-19 pandemic: consequences for nephrology | Nature Reviews Nephrology
CHENG, Y.; LUO, R.; WANG, K.; et al. Kidney disease is associated with in-hospital death of patients with COVID-19. Kidney International, v. 97, n. 5, p. 829–38, 2020. Kidney disease is associated with in-hospital death of patients with COVID-19 - PMC (nih.gov)
CONSORTIUM, N. C.-19 R.; RES, N. N. C.-19; HIRSCH, J. S.; et al. Acute kidney injury in patients hospitalized with COVID-19. Kidney International, v. 98, n. 1, p. 209–18, 2020. Acute kidney injury in patients hospitalized with COVID-19 - PMC (nih.gov)
CORVISIER1, R. L. DA C. T. C. S. E. F. S. A. V. G. M. F.; MENEZES1, M. A. DE M.; PEREIRA2, C. DA S. Á. E. C. DE F. S. S. R. N.; SIMVOULIDIS, L. F. N. O riginal A rticle | A rtigo O riginal Biomarkers of acute kidney injury in patients with nephrotic. Braz. J. Nephrol. (J. Bras. Nefrol.), v. 43, n. 3, p. 350–58, 2020. Acute kidney injury in patients with Covid-19 in a Brazilian ICU: incidence, predictors and in-hospital mortality - PMC (nih.gov)
GŁOWACKA, M.; LIPKA, S.; MŁYNARSKA, E.; FRANCZYK, B.; RYSZ, J. Acute Kidney Injury in COVID-19. International Journal of Molecular Sciences, v. 22, p. 1–11, 2021. Acute Kidney Injury in COVID-19 - PMC (nih.gov)
KAPP, M. E.; FOGO, A. B.; ROUFOUSE, C.; et al. Renal Considerations in COVID-19: Biology, Pathology, and Pathophysiology. ASAIO journal (American Society for Artificial Internal Organs : 1992), v. 67, n. 10, p. 1087–96, 2021. Renal Considerations in COVID-19: Biology, Pathology, and Pathophysiology - PMC (nih.gov)
KUBA, K.; IMAI, Y.; OHTO-NAKANISHI, T.; PENNINGER, J. M. Trilogy of ACE2: A peptidase in the renin-angiotensin system, a SARS receptor, and a partner for amino acid transporters. Pharmacology and Therapeutics, v. 128, n. 1, p. 119–28, 2010. Trilogy of ACE2: A peptidase in the renin–angiotensin system, a SARS receptor, and a partner for amino acid transporters - PMC (nih.gov)
MINISTÉRIO DA SAÚDE, B. Coronavírus. Disponível em: <https://www.gov.br/saude/pt-br/coronavirus>. Acesso em: 16/3/2022. Coronavírus — Português (Brasil) (www.gov.br)
MOLEDINA, D. G.; SIMONOV, M.; YAMAMOTO, Y.; et al. The Association of COVID-19 With Acute Kidney Injury Independent of Severity of Illness: A Multicenter Cohort Study. American Journal of Kidney Diseases, v. 77, n. 4, p. 490– 99.e1, 2021. The Association of COVID-19 With Acute Kidney Injury Independent of Severity of Illness: A Multicenter Cohort Study - American Journal of Kidney Diseases (ajkd.org)
NG, JIA H.; HIRSCH, J. S.; HAZZAN, A.; et al. Outcomes Among Patients Hospitalized With COVID-19 and Acute Kidney Injury. American Journal of Kidney Diseases, v. 77, n. 2, p. 204– 15.e1, 2021. Outcomes Among Patients Hospitalized With COVID-19 and Acute Kidney Injury - PMC (nih.gov)
OFFRINGA, A.; MONTIJN, R.; SINGH, S.; et al. The mechanistic overview of SARS-CoV-2 using angiotensin-converting enzyme 2 to enter the cell for replication: Possible treatment options related to the renin-angiotensin system. European Heart Journal - Cardiovascular Pharmacotherapy, v. 6, n. 5, p. 317–25, 2020. The mechanistic overview of SARS-CoV-2 using angiotensin-converting enzyme 2 to enter the cell for replication: possible treatment options related to the renin–angiotensin system - PMC (nih.gov)
PERICO, L.; BENIGNI, A.; REMUZZI, G. Should COVID-19 Concern Nephrologists? Why and to What Extent? the Emerging Impasse of Angiotensin Blockade. Nephron, v. 144, n. 5, p. 213–21, 2020. Should COVID-19 Concern Nephrologists? Why and to What Extent? The Emerging Impasse of Angiotensin Blockade - FullText - Nephron 2020, Vol. 144, No. 5 - Karger Publishers
RONCO, C.; REIS, T.; HUSAIN-SYED, F. Management of acute kidney injury in patients with COVID-19. The Lancet Respiratory Medicine, v. 8, n. 7, p. 738–42, 2020. Management of acute kidney injury in patients with COVID-19 - PMC (nih.gov)
SANCHIS-GOMAR, F.; LAVIE, C. J.; PEREZ-QUILIS, C.; HENRY, B. M.; LIPPI, G. Angiotensin-Converting Enzyme 2 and Antihypertensives (Angiotensin Receptor Blockers and Angiotensin-Converting Enzyme Inhibitors) in Coronavirus Disease 2019. , v. 95, n. June, p. 1222–30, 2020. Angiotensin-Converting Enzyme 2 and Antihypertensives (Angiotensin Receptor Blockers and Angiotensin-Converting Enzyme Inhibitors) in Coronavirus Disease 2019 - PMC (nih.gov)
SCHOLZ, J. R.; LOPES, M. A. C. Q.; SARAIVA, J. F. K.; COLOMBO, F. C. COVID-19, renin-angiotensin system, angiotensin-converting enzyme 2, and nicotine: What is the interrelation? Arquivos Brasileiros de Cardiologia, v. 115, n. 4, p. 708–11, 2020 COVID-19, Sistema Renina-Angiotensina, Enzima Conversora da Angiotensina 2 e Nicotina: Qual a Inter-Relação? - PMC (nih.gov)
SU, H.; YANG, M.; WAN, C.; et al. Renal histopathological analysis of 26 postmortem findings of patients with COVID-19 in China. Kidney International, v. 98, n. 1, p. 219–27, 2020. Renal histopathological analysis of 26 postmortem findings of patients with COVID-19 in China - Kidney International (kidney-international.org)
XU, C.; CHEN, Y.; YU, J. Foe and friend in the COVID-19-associated acute kidney injury: an insight on intrarenal renin-angiotensin system. Acta biochimica et biophysica Sinica, v. 54, n. 1, p. 1–11, 2022. Foe and friend in the COVID-19-associated acute kidney injury: an insight on intrarenal renin-angiotensin system (sciengine.com)
