Biodegradable synthetic polymers in biomedical application: A review

Polímeros sintéticos biodegradáveis em aplicação biomédica: Uma revisão

Authors

  • Andrea Alves de Souza
  • Rita de Cássia Braga Granja
  • Elisandra Cibely Cabral de Melo
  • Weslley Felix de Oliveira
  • Priscilla Barbosa Sales de Albuquerque
  • Maria Tereza dos Santos Correia
  • Maria das Graças Carneiro-da-Cunha

DOI:

https://doi.org/10.34119/bjhrv5n6-217

Keywords:

antimicrobial, drug delivery, healing

Abstract

Biotechnology associated with medical technology has allowed biodegradable synthetic polymers to have versatile and diversified biomedical applications due to interesting properties such as good cell adhesion, in vivo proliferation, and degradation without harmful effects to the human body. Thus, they are suitable for a variety of applications, especially those related to therapeutics or pharmaceutics, for example, tissue engineering and drug delivery. This work aimed to revise the broad applications of the term biodegradation in different areas of science. We focused on the most recent biomedical applications of biodegradable synthetic polymers, revising the characteristics which have contributed to solving health-related problems. Actual, efficient, and consistent results have been introduced in the market as a result of the growing search for new technologies. They have been applied both at macro and nanometer scales, in isolated and conjugated forms, or even as encapsulating matrices. Biodegradable synthetic polymers present longer degradation periods when compared to natural polymers, they stand out in tissue engineering since they can be adjusted according to their composition, reaching various degrees of selectivity for specific clinical applications.

References

Van der Zee, M. Analytical Methods for Monitoring Biodegradation Processes of Environmentally Degradable Polymers, first ed., in: Handbook of Biodegradable Polymers: Synthesis, Characterization and Applications, 2011, 263-281. https://doi.org/10.1002/9783527635818.ch11.

Hayashi, T. Biodegradable Polymers for Biomedical uses. Prog. Polym. Sci, 1994, 19, 663-702. https://doi.org/10.1016/0079-6700(94)90030-2.

Borhani, S.; Hassanajili, S.; Tafti S.; Rabbani, S. H. A. Cardiovascular stents: overview, evolution, and next generation. Prog. Biomater, 2018, 7(3), 175-205. https://doi.org/10.1007/s40204-018-0097-y.

Cvrček, L.; Horáková, M. Plasma Modified Polymeric Materials for Implant Applications, in: Non-Thermal Plasma Technology for Polymeric Materials. 2019, 367-407. https://doi.org/10.1016/B978-0-12-813152-7.00016-0.

Azimi, B.; Maleki, H.; Zavagna, L.; De la Ossa, J. G.; Linari, S.; Lazzeri, A.; Danti, S. Bio-based electrospun fibers for wound healing. J. Funct. Biomater, 2020, 11(3), 67. https://doi.org/10.3390/jfb11030067.

Toong, D. W. Y.; Toh, H. W.; Ng, J. C. K.; Wong, P. E. H.; Leo, H. L.; Venkatraman, S.; Huang, Y. Bioresorbable Polymeric Scaffold in Cardiovascular Applications.

Int. J. Mol. Sci, 2020, 21(10), 3444. https://doi.org/10.3390/ijms21103444.

Yi, S.; Xu, L.; Gu, X. Scaffolds for peripheral nerve repair and reconstruction. Exp. Neurol, 2019, 319, 112761. https://doi.org/10.1016/j.expneurol.2018.05.016.

Ilhan, E.; Ulag, S.; Sahin, A.; Yilmaz, B. K.; Ekren, N.; Kilic, O.; Gunduz, O. Fabrication of tissue-engineered tympanic membrane patches using 3D-Printing technology. J. Mech. Behav. Biomed. Mater, 2021, 114, 104-219. https://doi.org/ 10.1016/j.jmbbm.2020.104219.

Singhvi, M. S.; Singhvi, S. S.; Zinjarde, D. V.; Gokhale. Poly-Lactic acid: synthesis and biomedical applications. J. Appl. Microbiol, 2019. 127(6), 1612-1626. https://doi.org/10.1111/jam.14290.

Aynali, F.; Balci, H.; Doganci, E.; Bulus, E. Production and characterization of non-leaching antimicrobial and hydrophilic polycaprolactone based nanofiber mats. Eur. Polym. J, 2021, 149, 110-368. https://doi.org/10.1016/j.eurpolymj.2021.110368.

Huang, Q.; Liu, Y.; Ouyang, Z.; Feng. Q. Comparing the regeneration potential between PLLA/Aragonite and PLLA/Vaterite pearl composite scaffolds in rabbit radius segmental bone defects, Bioact. Mater, 2020, 5(4), 980-989. https://doi.org/ 10.1016/ j.bioactmat.2020.06.018.

Shi, K.; Wang, Y. L.; Qu, Y.; Liao, J. F.; Chu, B. Y.; Zhang, H. P.; Qian, Z. Y. Synthesis, characterization, and application of reversible PDLLA-PEG-PDLLA copolymer thermogels in vitro and in vivo. Sci. Rep, 2016, 6, 19077. https://doi.org/10.1038/srep19077.

Diaz-Gomez, L.; Elizondo, M. E.; Koons, G. L.; Diba, M.; Chim, L. K.; Cosgriff-Hernandez, E.; Mikos, A. G. Fiber engraving for bioink bioprinting within 3D printed tissue engineering scaffolds. Bioprinting, 2020, 18, e00076. https://doi.org/10.1016/ j.bprint.2020.e00076.

Zhang, H.; Jiao, J.; Jin, H. Degradable poly-L-lysine-modified PLGA cell microcarriers with excellent antibacterial and osteogenic activity. Artif. Cells Nanomed. Biotechnol, 2019, 47(1), 2391-2404. https://doi.org/10.1080/21691401.2019.1623230.

Fu, T. S.; Wei, Y. H.; Cheng, P. Y.; Chu, I.; Chen, W. C. A novel biodegradable and thermosensitive poly (ester-amide) hydrogel for cartilage tissue engineering. Biomed Res. Int, 2018, 2710892, https://doi.org/10.1155/2018/2710892.

Rudnik-Jansen, I.; Tellegen, A.; Beukers, M.; Öner, F.; Woike, N.; Mihov, G.; Creemers L. Safety of intradiscal delivery of triamcinolone acetonide by a poly (esteramide) microsphere platform in a large animal model of intervertebral disc degeneration. Spine J., 2019, 19(5)905-919 https://doi.org/10.1016/j.spinee.2018.10.014.

Dou, J.; Wang, Y.; Jin, X.; Li, P.; Wang, L.; Yuan, J.; Shen, J. PCL/sulfonated keratin mats for vascular tissue engineering scaffold with potential of catalytic nitric oxide generation, Mater.Sci.Eng.C, 2020, 107110246. https://doi.org/ 10.1016/ j.msec.2019.110246.

Bhattacharya, S.; Hailstone, R.; Lewis, C. L. Thermoplastic Blend Exhibiting Shape Memory-Assisted Self-Healing Functionality. ACS Appl. Mater. Interfaces, 2020, 12(41), 46733-46742. https://doi.org/10.1021/acsami.0c13645.

Le Low, J.; Kao, P. H. N.; Tambyah, P. A.; Koh, G. L. E.; Kline, H.; Ling, K. A.; Leong S. S. J. Development of a polymer-based antimicrobial coating for efficacious urinary catheter protection. Biotechnology Notes, 2021, 2, 1-10. https://doi.org/10.1016/j.biotno.2020.12.001.

Zamani, M.; Rostamizadeh, K.; Manjili, H. K.; Danafar, H. In vitro and in vivo biocompatibility study of folate-lysine-PEG-PCL as nanocarrier for targeted breast cancer drug delivery. Eur. Polym. J, 2018, 103, 260-279. https://doi.org/10.1016/j.eurpolymj.2018.04.020.

Risley, B. B.; Ding, X.; Chen, Y.; Miller, P. G.; Wang, Y. Citrate crosslinked poly (glycerol sebacate) with tunable elastomeric properties. Macromol. Biosci, 2021, 21(2), 2000301. https://doi.org/10.1002/mabi.202000301.

Zhao, X.; Wu, H.; Guo, B.; Dong, R.; Qiu, Y.; Ma, P. X. Antibacterial anti-oxidant electroactive injectable hydrogel as self-healing wound dressing with hemostasis and adhesiveness for cutaneous wound healing. Biomaterials, 2017, 122, 34-47. https://doi.org/10.1016/j.biomaterials.2017.01.011.

Chegini S. P.; Varshosaz, J.; Sadeghi, H. M.; Dehgani, A.; Minayian, M. Poly (glycerol sebacate) nanoparticles for ocular delivery of sunitinib: physicochemical, cytotoxic and allergic studies. IET nanobiotechnology, 2019, 13(9), 974-982. https://doi.org/10.1049/iet-nbt.2019.0002.

Yeoh, F. H.; Lee, C. S.; Kang, Y. B.; Wong, S. F.; Cheng, S. F.; Ng, W.S. Production of Biodegradable Palm Oil-Based Polyurethane as Potential Biomaterial for Biomedical Applications. Polymers, 2020, 12(8), 1842. https://doi.org/10.3390/polym12081842.

Iyer, R.; Nguyen, T.; Padanilam, D.; Xu, C.; Saha, D.; Nguyen, K. T.; Hong, Y. Glutathione-responsive biodegradable polyurethane nanoparticles for lung cancer treatment. J. Control. Release, 2020, 321, 363-371. https://doi.org/ 10.1016/ j.jconrel.2020.02.021.

Wang, C.; Yi, Z.; Sheng, Y.; Tian, L.; Qin, L.; Ngai, T.; Lin, W. Development of a novel biodegradable and anti-bacterial polyurethane coating for biomedical magnesium rods. Mater. Sci. Eng. C, 2019, 99, 344-356. https://doi.org/10.1016/j.msec.2019.01.119.

Ojansivu, M.; Johansson, L.; Vanhatupa, S.; Tamminen, I.; Hannula, M.; Hyttinen, J.; Miettinen, S. Knitted 3D scaffolds of polybutylene succinate support human mesenchymal stem cell growth and osteogenesis. Stem Cells Int., 2018, 5928935. https://doi.org/10.1155/2018/5928935.

Ulery, B. D.; Nair, L. S.; Laurencin, C. T. Biomedical applications of biodegradable polymers. J. Polym. Sci. B Polym. Phy., 2011, 49(12), 832-864. https://doi.org/10.1002/polb.22259.

Samantaray, P. K.; Little, A.; Haddleton, D.M.; McNally, T.; Tan, B.; Sun, Z.; Wan, C. Poly(glycolic acid)(PGA): a versatile building block expanding high performance and sustainable bioplastic applications. Green Chem., 2020, 22(13), 4055-4081. https://doi.org/10.1039/D0GC01394C.

Farah, S.; Anderson, D.G.; Langer, R. Physical and mechanical properties of PLA, and their functions in widespread applications—A comprehensive review. Adv. Drug Deliv. Rev., 2016, 107(15), 367-392. https://doi.org/10.1016/j.addr.2016.06.012.

Armentano, I.; Gigli, M.; Morena, F.; Argentati, C.; Torre, L.; Martino, S. Recent advances in nanocomposites based on aliphatic polyesters: design, synthesis, and applications in regenerative medicine. Appl. Sci., 2018, 8(9) (2018) 1452. https://doi.org/10.3390/app8091452.

Laubach, J.; Joseph, M.; Brenza, T.; Gadhamshetty, V.; Sani, R.K. Exopolysaccharide and biopolymer-derived films as tools for transdermal drug delivery, J. Control. Release, 2021, 329, 971-987. https://doi.org/10.1016/j.jconrel.2020.10.027.

Singha, S. & Hedenqvist, M. S. A Review on Barrier Properties of Poly (Lactic Acid)/Clay Nanocomposites, Polymers, 2020, 12(5) 1095. https://doi.org/ 10.3390/polym12051095.

Shao, J.; Cao, S.; Williams, D.S.; Abdelmohsen, L.K.; Van Hest, J.C. Photoactivated polymersome nanomotors: traversing biological barriers, Angew. Chem. Int. Ed., 2020, 59(39), 16918-16925. https://doi.org/10.1002/anie.202003748.

Zare, E.N.; Jamaledin, R.; Naserzadeh, P.; Afjeh-Dana, E.; Ashtari, B.; Hosseinzadeh, M.; Makvandi, P. Metal-Based nanostructures/PLGA nanocomposites: antimicrobial activity, cytotoxicity, and their biomedical applications, ACS Appl. Mater. Interfaces, 2020, 12(3), 3279-3300. https://doi.org/10.1021/acsami.9b19435.

Nilawar, S.; Dasgupta, Q.; Madras, G.; Chatterjee, K. Degradable poly(ester amide)s from olive oil for biomedical applications, Emerg. Mater., 2019, 2, 153-168. https://doi.org/10.1007/s42247-019-00032-w.

Pinho, A.C.; Fonseca, A.C.; Caseiro, A.R.; Pedrosa, S.S.; Amorim, I.; Branquinho, M.V.; Coelho, J.F.J. Innovative tailor made dextran based membranes with excellent non-inflammatory response: In vivo assessment, Mater. Sci. Eng., 2020, 107, 110243. https://doi.org/10.1016/j.msec.2019.110243.

Abudula, T.; Gauthaman, K.; Hammad, A.H.; Joshi Navare, K.; Alshahrie, A.A.; Bencherif, S.A.; Memic, A. Oxygen-releasing antibacterial nanofibrous scaffolds for tissue engineering applications, Polymers, 2020, 12(6), 1233. https://doi.org/10.3390/polym12061233.

Perin, G.B. & Felisberti, M.I. Enzymatic synthesis of poly(glycerol sebacate): kinetics, chain growth, and branching behavior, Macromolecules, 2020, 53(18), 7925-7935. https://doi.org/10.1021/acs.macromol.0c01709.

Abudula, T.; Gzara, L.; Simonetti, G.; Alshahrie, A.; Salah, N.; Morganti, P.; Memic, A. The effect of poly (glycerol sebacate) incorporation within hybrid chitin–lignin sol–gel nanofibrous scaffolds, Materials, 2018, 11(3), 451. https://doi.org/10.3390/ma11030451.

Wendels, S. & Avérous, L. Biobased polyurethanes for biomedical applications, Bioact. Mater., 2021, 6(4), 1083–1106. https://doi.org/10.1016/j.bioactmat.2020.10.002.

Ozgok, K.M.K. & Regan, J.P. Wound Healing. [Updated 2022 May 8]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing, 2022 Jan. https://www.ncbi.nlm.nih.gov/books/NBK535406.

Wallace, H.A.; Basehore, B.M.; Zito, P.M. Wound Healing Phases. [Updated 2021 nov 15]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan. https://www.ncbi.nlm.nih.gov/books/NBK470443.

Binotto, J.P.; Mendes, L.G.; Gaspi, F.O.D.G.; Esquisatto, M.A.M.; Andrade, T.A.M.D.; Mendonça, F.A.S.; Santos, G.M.T. Poly (Lactic Acid) membrane and Sedum dendroideum extract favors the repair of burns in rats, Acta Cir. Bras., 2020, 35(3), e202000302. https://doi.org/10.1590/s0102-865020200030000002.

Marins, N.H.; Silva, R.M.; Ferrua, C.P.; Łukowiec, D.; Barbosa, A.M.; Ribeiro, J.S.; Carreño, N.L. Fabrication of electrospun poly (lactic acid) nanoporous membrane loaded with niobium pentoxide nanoparticles as a potential scaffold for biomaterial applications, J. Biomed. Mater. Res. Part B Appl. Biomater., 2020, 108(4), 1559-1567. https://doi.org/10.1002/jbm.b.34503.

Wang, C.C.; Shih, T.Y.; Hsieh, Y.T.; Huang, J.L.; Wang, J. l-Arginine grafted poly (glycerol sebacate) materials: an antimicrobial material for wound dressing, Polymers, 2020, 12(7), 1457. https://doi.org/10.3390/polym12071457.

Zhang, W.; Weng, T.; Li, Q.; Jin, R.; You, C.; Wu, P.; Wang, X. Applications of poly (caprolactone)-based nanofibre electrospun scaffolds in tissue engineering and regenerative medicine, Curr Stem Cell Res Ther., 2021, 16(4), 414-442. https://doi.org/10.2174/1574888X15666201014145703.

Christen, M.O. & Vercesi, F. Polycaprolactone: How a well-known and futuristic polymer has become an innovative collagen-stimulator in esthetics, Clin. Cosmet. Investig. Dermatol., 2020, 13, 31-48. https://doi.org/10.2147/CCID.S229054.

Radhakrishnan, S.; Nagarajan, S.; Belaid, H.; Farha, C.; Iatsunskyi, I.; Coy, E.; Bechelany, M. Fabrication of 3D printed antimicrobial polycaprolactone scaffolds for tissue engineering applications, Mater. Sci. Eng. C., 2021, 118, 111525. https://doi.org/10.1016/j.msec.2020.111525.

Hodge, J. & Quint, C. Tissue engineered vessel from a biodegradable electrospun scaffold stimulated with mechanical stretch Biomed. Mater., 2020, 15(5), 055006. https://doi.org/10.1088/1748-605X/ab8e98.

Zeng, Y.; Li, X.; Liu, X.; Yang, Y.; Zhou, Z.; Fan, J.; Jiang, H. PLLA Porous microsphere-reinforced silk-based scaffolds for auricular cartilage regeneration, ACS Omega., 2021, 6(4) 3372-3383. https://doi.org/10.1021/acsomega.0c05890.

Montesanto, S.; Smithers, N.P.; Bucchieri, F.; Brucato, V.; La Carrubba, V.; Davies, D.E.; Conforti, F. Establishment of a pulmonary epithelial barrier on biodegradable poly-L-lactic-acid membranes, PloS one., 2019, 14(1) e0210830. https://doi.org/ 10.1371/journal.pone.0210830.

Babilotte, J.; Martin, B.; Guduric, V.; Bareille, R.; Agniel, R.; Roques, S.; Catros, S. Development and characterization of a PLGA-HA composite material to fabricate 3D-printed scaffolds for bone tissue engineering, Mater. Sci. Eng. C., 2021, 118, 111334. https://doi.org/10.1016/j.msec.2020.111334.

Scaffaro, R.; Lopresti, F.; Marino, A.; Nostro, A. Antimicrobial additives for poly (lactic acid) materials and their applications: current state and perspectives, Appl. Microbiol. Biotechnol., 2018, 102(18), 7739-7756. https://doi.org/10.1007/s00253-018-9220-1.

Roy, S. & Rhim, J.W. Preparation of bioactive functional poly (lactic acid)/curcumin composite film for food packaging application, Int. J. Biol. Macromol., 2020, 162, 1780-1789. https://doi.org/10.1016/j.ijbiomac.2020.08.094.

Pelaseyed, S.S.; Hosseini, H.R.M.; Nokhbedehghan, Z.; Samadikuchaksaraei, A. PLGA/TiO2 nanocomposite scaffolds for biomedical applications: fabrication, photocatalytic, and antibacterial properties, BioImpacts: BI, 2021, 11(1), 45-52. https://doi.org/10.34172/bi.2021.06.

Boncu, T.E.; Guclu, A.U.; Catma, M.F.; Savaser, A.; Gokce, A.; Ozdemir, N. In vitro and in vivo evaluation of linezolid loaded electrospun PLGA and PLGA/PCL fiber mats for prophylaxis and treatment of MRSA induced prosthetic infections,

Int. J. Pharm., 2020, 573, 118758. https://doi.org/10.1016/j.ijpharm.2019.118758.

Muñoz-Escobar, A. & Reyes-López, S.Y. Antifungal susceptibility of Candida species to copper oxide nanoparticles on polycaprolactone fibers (PCL-CuONPs), PloS one., 2020, 15(2), e0228864. https://doi.org/10.1371/journal.pone.0228864.

Karakucuk, A. & Tort, S. Preparation, characterization and antimicrobial activity evaluation of electrospun PCL nanofiber composites of resveratrol nanocrystals, Pharm. Dev. Technol., 2020, 25(10), 1216-1225. https://doi.org/10.1080/ 10837450.2020.1805761.

Kong, D.; Shi, Y.; Gao, Y.; Fu, M.; Kong, S.; Lin, G. Preparation of BMP-2 loaded MPEG-PCL microspheres and evaluation of their bone repair properties, Biomed. Pharmacother, 2020, 130, 110516. https://doi.org/10.1016/j.biopha.2020.110516.

Darge, H.F.; Andrgie, A.T.; Hanurry, E.Y.; Birhan, Y.S.; Mekonnen, T.W.; Chou, H.Y.; Tsai, H.C. Localized controlled release of bevacizumab and doxorubicin by thermo-sensitive hydrogel for normalization of tumor vasculature and to enhance the efficacy of chemotherapy, Int. J. Pharm., 2019, 572, 118799. https://doi.org/10.1016/j.ijpharm.2019.118799.

Jin, X.; Fu, Q.; Gu, Z.; Zhang, Z.; Lv, H. Injectable corilagin/low molecular weight chitosan/PLGA-PEG-PLGA thermosensitive hydrogels for localized cancer therapy and promoting drug infiltration by modulation of tumor microenvironment, Int. J. Pharm., 2020, 589, 119772. https://doi.org/10.1016/j.ijpharm.2020.119772.

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12/16/2022

How to Cite

SOUZA, A. A. de; GRANJA, R. de C. B.; MELO, E. C. C. de; OLIVEIRA, W. F. de; ALBUQUERQUE, P. B. S. de; CORREIA, M. T. dos S.; CARNEIRO-DA-CUNHA, M. das G. Biodegradable synthetic polymers in biomedical application: A review: Polímeros sintéticos biodegradáveis em aplicação biomédica: Uma revisão. Brazilian Journal of Health Review, [S. l.], v. 5, n. 6, p. 24628–24644, 2022. DOI: 10.34119/bjhrv5n6-217. Disponível em: https://ojs.brazilianjournals.com.br/ojs/index.php/BJHR/article/view/55457. Acesso em: 18 oct. 2026.

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