Emplastro de lidocaína para tratamento da dor na osteoartrite de joelho: revisão sistemática

Lidocaine emplaster for treatment of pain in knee osteoarthritis: systematic review

Authors

  • Stephane Mirella Costa Alves
  • Fernando Vítor Gama Borges
  • David Sadigursky
  • Matheus Lemos Azi

DOI:

https://doi.org/10.34119/bjhrv5n6-210

Keywords:

emplastro de lidocaína, osteoartrite, joelho

Abstract

Objetivo: Determinar a eficácia do emplastro de lidocaína 5% para controle álgico, melhora da rigidez articular e da incapacidade física em pacientes portadores da osteoartrite do joelho. Metodologia: Essa revisão sistemática teve o protocolo PRISMA como método de busca de artigos e um total 5 estudos (4 ensaios clínicos e 1 coorte) foram identificados para análise sobre o uso do emplastro de lidocaína 5% no tratamento da osteoartrite do joelho num período que variou de 11 dias a 12 semanas. Uma população total de 355 indivíduos foi avaliada através da escala de WOMAC, amplitude de movimento (ADM) e nível de dor pela escala visual analógica (EVA). Resultados: Apesar de os ensaios clínicos possuírem uma qualidade inferior à coorte, houve uma melhora geral dos escores do WOMAC e o uso isolado do emplastro de lidocaina mostrou equivalência analgésica quando comparado aos opiódes orais. Conclusão: O emplastro de lidocaína é eficaz para a melhora da dor, da rigidez articular e da incapacidade física nos pacientes com osteoartrite do joelho, e possui resultados semelhantes quando comparamos com analgésicos opiódes orais, sendo uma opção com menos efeitos adversos para o tratamento da dor na osteoartrite. 

References

Khanna M, Peters C, Singh JR. Treating pain with the lidocaine patch 5% after total knee arthroplasty. PM&R. 2012;4(9):642–646.

Galer BS, Sheldon E, Patel N, Codding C, Burch F, Gammaitoni AR. Topical lidocaine patch 5% may target a novel underlying pain mechanism in osteoarthritis. Curr Med Res Opin. 2004;20(9):1455–1458.

Longo DL, Fauci AS, Kasper DL, others. eds. Harrison’s principles of internal medicine. 18th edn The McGraw-Hill Companies. Inc; 2012.

Kivitz A, Fairfax M, Sheldon EA, Xiang Q, Jones BA, Gammaitoni AR, et al. Comparison of the effectiveness and tolerability of lidocaine patch 5% versus celecoxib for osteoarthritis-related knee pain: post hoc analysis of a 12 week, prospective, randomized, active-controlled, open-label, parallel-group trial in adults. Clin Ther. 2008;30(12):2366–2377.

Burch F, Codding C, Patel N, Sheldon E. Lidocaine patch 5% improves pain, stiffness, and physical function in osteoarthritis pain patients: a prospective, multicenter, open-label effectiveness trial. Osteoarthritis Cartilage. 2004;12(3):253–255.

Bitton R. The economic burden of osteoarthritis. Am J Manag Care. 2009;15(8 Suppl):S230–5.

Baliki MN, Geha PY, Jabakhanji R, Harden N, Schnitzer TJ, Apkarian AV. A preliminary fMRI study of analgesic treatment in chronic back pain and knee osteoarthritis. Mol Pain. 2008 Oct 25;4:47.

Stanos SP. Topical agents for the management of musculoskeletal pain. J Pain Symptom Manage. 2007 Mar;33(3):342–55.

Rezende MU de, Gobbi RG. Tratamento medicamentoso da osteoartrose do joelho. Rev Bras Ortop. 2009;44(1):14–19.

Flores MP, de Castro APCR, Nascimento J dos S. Analgésicos tópicos. Rev Bras Anestesiol. 2012;244–252.

Díaz-Heredia J, Loza E, Cebreiro I, Iban MR. Analgesia preventiva en artroplastia de cadera o rodilla: una revisión sistemática. Rev Esp Cir Ortopédica Traumatol. 2015;59(2):73–90.

Fraenkel L, Bogardus ST, Concato J, Wittink DR. Treatment options in knee osteoarthritis: the patient’s perspective. Arch Intern Med. 2004 Jun 28;164(12):1299–304.

Prostran M, Vujović KS, Vučković S, Medić B, Srebro D, Divac N, et al. Pharmacotherapy of Pain in the Older Population: The Place of Opioids. Front Aging Neurosci [Internet]. 2016;8. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4909762/

Hendolin H, Nuutinen L, Kokki H, Tuomisto L. Does morphine premedication influence the pain and consumption of postoperative analgesics after total knee arthroplasty? Acta Anaesthesiol Scand. 1996 Jan;40(1):81–5.

Reiter A, Zulus E, Hartmann T, Hoerauf K. Preoperative oral administration of fast-release morphine sulfate reduces postoperative piritramide consumption. Wien Klin Wochenschr. 2003 Jul 15;115(12):417–20.

Pasero C. Lidocaine patch 5% for acute pain management. J Perianesthesia Nurs Off J Am Soc PeriAnesthesia Nurses. 2013 Jun;28(3):169–73.

Carter GT, Galer BS. Advances in the management of neuropathic pain. Phys Med Rehabil Clin N Am. 2001;12(2):447–459.

Gammaitoni AR, Alvarez NA, Galer BS. Safety and tolerability of the lidocaine patch 5%, a targeted peripheral analgesic: a review of the literature. J Clin Pharmacol. 2003 Feb;43(2):111–7.

Moher D, Liberati A, Tetzlaff J, Altman DG, Group P, others. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. PLoS Med. 2009;6(7):e1000097.

Jadad AR, Moore RA, Carroll D, Jenkinson C, Reynolds DJ, Gavaghan DJ, et al. Assessing the quality of reports of randomized clinical trials: is blinding necessary? Control Clin Trials. 1996 Feb;17(1):1–12.

Wells GA, Shea B, O’connell D, Peterson J, Welch V, Losos M, et al. The Newcastle-Ottawa Scale (NOS) for assessing the quality if nonrandomized studies in meta-analyses. 2009. Epub Available URL Httpwww Ohri Caprogramsclinicalepidemiologyoxford Htm Cited 2009 Oct 19. 2013;

Dworkin RH, Jensen MP, Gould E, Jones BA, Xiang Q, Galer BS, et al. Treatment satisfaction in osteoarthritis and chronic low back pain: the role of pain, physical and emotional functioning, sleep, and adverse events. J Pain Off J Am Pain Soc. 2011 Apr;12(4):416–24.

Burns LC, Ritvo SE, Ferguson MK, Clarke H, Seltzer Z ’ev, Katz J. Pain catastrophizing as a risk factor for chronic pain after total knee arthroplasty: a systematic review. J Pain Res. 2015;8:21–32.

Derry S, Wiffen PJ, Moore RA, Quinlan J. Topical lidocaine for neuropathic pain in adults. Cochrane Database Syst Rev [Internet]. 2014;7. Available from: http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD010958/full

Kim KH. Use of lidocaine patch for percutaneous endoscopic lumbar discectomy. Korean J Pain. 2011 Jun;24(2):74–80.

Rowbotham MC, Davies PS, Verkempinck C, Galer BS. Lidocaine patch: double-blind controlled study of a new treatment method for post-herpetic neuralgia. Pain. 1996 Apr;65(1):39–44.

Moon JY, Choi JB, Lee PB, Son HM, Nam FS, Kim YC, et al. An open-label trial of the 5% lidocaine patches for the treatment of chronic pain. Korean J Pain. 2009;22(3):216–223.

Anastase DM, Cionac Florescu S, Munteanu AM, Ursu T, Stoica CI. Analgesic techniques in hip and knee arthroplasty: from the daily practice to evidence-based medicine. Anesthesiol Res Pract [Internet]. 2014;2014. Available from: https://www.hindawi.com/journals/arp/2014/569319/abs/

Potty AG, Tzeng TH, Sams JD, Lovell ME, Mihalko WM, Thompson KM, et al. Diagnosis and Management of Intra-articular Causes of Pain After Total Knee Arthroplasty. Instr Course Lect. 2015;64:389–401.

Gilhooly D, McGarvey B, O’Mahony H, O’Connor TC. Topical lidocaine patch 5% for acute postoperative pain control. BMJ Case Rep. 2011;2011:bcr0620103074.

Husain S, Gusmorino P, Vitale K, Fedman D, Jimenez A. A randomized, double-blind controled study looking at lidoderm patch efficacy in reducing pain and improving function in patients with unilateral knee replacements. J Pain. 2009;10(4):S62.

Thakur M, Dickenson AH, Baron R. Osteoarthritis pain: nociceptive or neuropathic? Nat Rev Rheumatol 2014;10:374–80.

Wylde V, Beswick A, Bruce J, et al. Chronic pain after total knee arthroplasty. EFORT Open Rev 2018;3:461–70.

Bedson J, Croft PR. The discordance between clinical and radiographic knee osteoarthritis: a systematic search and summary of the literature. BMC Musculoskelet Disord 2008;9:116.

Published

12/15/2022

How to Cite

ALVES, S. M. C.; BORGES, F. V. G.; SADIGURSKY, D.; AZI, M. L. Emplastro de lidocaína para tratamento da dor na osteoartrite de joelho: revisão sistemática: Lidocaine emplaster for treatment of pain in knee osteoarthritis: systematic review. Brazilian Journal of Health Review, [S. l.], v. 5, n. 6, p. 24552–24564, 2022. DOI: 10.34119/bjhrv5n6-210. Disponível em: https://ojs.brazilianjournals.com.br/ojs/index.php/BJHR/article/view/55428. Acesso em: 17 oct. 2026.

Issue

Section

Original Papers