Avaliação tríplice da mama: a importância da análise citológica preliminar
Triple breast assessment: the importance of preliminary cytological analysis
DOI:
https://doi.org/10.34119/bjhrv5n5-263Keywords:
PAAF, câncer, citopatologistaAbstract
Quando detectado e tratado precocemente, o câncer de mama tem bom prognóstico. Estudos demonstram que um atraso de mais de três meses entre a identificação dos sintomas e o tratamento está associado a uma redução de 12% na sobrevida para pacientes com câncer de mama. A avaliação preliminar de materiais obtidos de nódulos palpáveis na mama, na primeira consulta, pode ter um impacto positivo sobre o tempo e a precisão dos procedimentos diagnósticos. Objetivou-se, com esta pesquisa, investigar a importância e aspectos positivos da análise citológica preliminar de material colhido por PAAF, em nódulos palpáveis de mama para antecipar o tempo decorrido entre a primeira consulta e os tratamentos, em casos positivos, bem como para evitar danos emocionais nas pacientes com resultados preliminares positivos. Foi realizado uma revisão sistemática da literatura utilizando-se artigos publicados em português ou em inglês, encontrados a partir dos seguintes descritores em saúde: “citologia aspirativa por agulha fina”, “câncer de mama”, “Citopatologia” e “panóptico”. Os resultados apontam que a análise preliminar de nódulos palpáveis de mama, obtidos por Punção Aspirativa por Agulha Fina - PAAF é um meio eficaz de maximizar as chances de sucesso na aquisição células tumorais adequadas para diagnóstico e estudos. Há concordância dos autores quanto a importância do citopatologista auxiliar o mastologista na primeira consulta para realizar análise imediata do material colhido por PAAF, pois além de agilizar o estadiamento da doença, reduz os danos emocionais, nas pacientes, causados pela expectativa de resultados laboratoriais, além de evitar custos econômicos e transtornos de viagens para mulheres que residem distante de locais de atendimento clínico. Ademais, há relatos de que a análise preliminar tem favorecido a celeridade dos procedimentos necessários nos casos que necessitam de cirurgias, garantindo as chances de cura.
References
Abdel-Hadi M, Abdel-Hamid Gehane F., Abdel-Razek, M.D, Rawia K. Fawzy. Should Fine-Needle Aspiration Cytology be the First Choice Diagnostic Modality for Assessment of All Nonpalpable Breast Lesions? The Experience of a Breast Cancer Screening Center in Alexandria, Egypt. Diagnostic Cytopathology 2010, Vol 38, No 12.
Abdel-Hadi, M.; Abdel-Hamid, GF.; Abdel-Razek, M.D; Fawzy, RK. Should Fine-Needle Aspiration Cytology be the First Choice Diagnostic Modality for Assessment of All Nonpalpable Breast Lesions? The Experience of a Breast Cancer Screening Center in Alexandria, Egypt. Diagnostic Cytopathology, Vol 38, No 12, 2010.
Alkuwari, A.; Auger, M. Accuracy of Fine-Needle Aspiration Cytology of Axillary Lymph Nodes in Breast Cancer Patients A Study of 115 Cases With Cytologic-Histologic Correlation. CANCER (CANCER CYTOPATHOLOGY), 2008 / Volume 114 / Number 2.
Ángeles-Llerenas A, Torres-Mejía G, Lazcano-Ponce E, Uscanga-Sánchez S, Mainero-Ratchelous F, Hernández-Ávila JE, et al. Effect of care-delivery delay on the survival of Mexican women with breast cancer. Salud Publica Mex. 2016;58(2):237-50.
Apesteguia L, Pina L, Inchusta M, et al. Nonpalpable, well-defined, probably benign breast lesion: management by fine-needle aspiration biopsy and long-interval follow-up mammography. Eur Radiol 1997;7:1235–1239.
Ariga R, Bloom K, Reddy VB, Kluskens L, Francescatti D, Dowlat K, Siziopikou P, Gattuso P. Fine-needle aspiration of clinically suspicious palpable breast masses with histopathologic correlation. Am J Surg. 2002 Nov;184(5):410-3.
Bezerra, ALR.; Bezerra, MCM.; Santos, AFFL; Lima, FM; Almeida, ITB; Ferreira, LMG. Evaluation of delays in diagnosis and Treatment of breast cancer in a reference Center: a retrospective analysis. Mastology. P 1-8, 2019.
Dixon JM, Clarke PJ, Crucioli V, Dehn TC, Lee EC, Greenall MJ. Reduction of the surgical excision rate in benign breast disease using fine needle aspiration cytology with immediate reporting. Br J Surg 1987; 74: 1014-6.
Duguid HLD, Wood RAB, Irving AD, Preece AD, Cuschieri A. Needle aspiration of the breast with immediate reporting of material. Br Med J 1979;2:185-7.
Boerner S, Fornage BD, Singletary E, Sneige N. Ultrasound-guided fine-needle aspiration of nonpalpable breast lesions: A review of 1885 FNA cases using the National Cancer Institute-supported recommendations on the uniform approach to breast FNA. Cancer 1999; 87:19–24.
Bonifazi M, Sediari M, Ferretti M, et al. The role of the pulmonologist in rapid on-site cytologic evaluation of transbronchial needle aspiration: a prospective study. Chest. 2014;145:60-65.
Brasil. Presidência da República Casa Civil. Subchefia para Assuntos Jurídicos. LEI Nº 12.732, DE 22 DE NOVEMBRO DE 2012. Disponivel em: http://www.planalto.gov.br/ccivil_03/_ato2011-2014/2012/lei/l12732.htm. Acesso em: 24/02/2022.
Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A (2018) Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 68:394–424
Brito C, Portela MC, Vasconcellos MT. Sobrevida de mulheres tratadas por câncer de mama no estado do Rio de Janeiro. Rev Saúde Pública. 2009;43(3):481-9.
Bueno Angela SP, Viero RM, Soares CT (2013) Fine needle aspirate cell blocks are Center: a retrospective analysis. Mastology, 2019;29(3):144-15.
Ciatto S, Rosselli del Turco M, Ambrogetti D, et al. Solid nonpalpable breast lesions: success and failure of guided fine-needle aspiration cytology in a consecutive series of 2444 cases. Acta Radiol 1997;38:815–820.
Collins BT, Chen AC, Wang JF, et al. Improved laboratory resource utilization and patient care with the use of rapid on-site evaluation for endobronchial ultrasound fine-needle aspiration biopsy. Cancer Cytopathol. 2013;121:544-551.
Dacic S. Molecular genetic testing for lung adenocarcinomas: a practical approach to clinically relevant mutations and translocations. J Clin Pathol 2013; 66: 870-4.
Dantas KAN, Santos GC, Giannotti Filho O. Sistemas de graduação para carcinoma de mama: estudo comparativo da concordância citohistológica. Rev Bras Ginecol Obstet. 2003;25(2):87-92.
Dinas C; Pratilas GC; Nasioutziki M; Vavoulidis E; Makris V; Loufopoulos PD; Kalder M. Clinical Signifi cance of Fine Needle Aspiration in Managing Patients. Falando sobre câncer de mama. – Rio de Janeiro: MS/INCA, 2002.
Ferreira NAS, Carvalho SMF, Valenti VE, Bezerra IMP, Batista HMT, Abreu LC, et al. Treatment delays among women with breast cancer in a low socio-economic status region in Brazil. BMC Womens Health. 2017;17(1):13.
Globocan Observatory W (2021) Cancer today - world. Int Agency Res Cancer https://gco.iarc.fr/today/data/factsheets/populations/900-world-fact-sheets.pdf. Accesso em 01/12/2021.
INCA. Instituto Nacional de Câncer. Coordenação de Prevenção e Vigilância – (Conprev)
Instituto Nacional do Câncer. Detecção precoce do câncer de mama. 2018. Disponível em https://www.inca.gov.br/controle-do-cancer-de-mama/acoes-de-controle. Acesso 23/02/2022.
Kaufman Z, Shpitz B, Shapiro M, et al. Triple approach in the diagnosis of dominant breast mass: combined physical examination, mammography, and fine-needle aspiration. J SurgOncol, 1994; 56: 254-7.
Keebler, Catherine (1993). The manual of cytotechnology (7th ed.). Chicago: ASCP Press. Kemp C, Elias S, Borrelli K, Narvaiza DG, Kemp CGM, Schor AP. Punção aspirativa por agulha fina orientada por ultra-sonografia em lesões não-palpáveis. Rev Bras Ginecol Obstet. 2001;23(5):321-7.
Kocjan G, Bourgain C, Fassina A, et al. The role of breast FNAC in diagnosis and clinical management: a survey of current practice. Cytopathology 2008;19:271-8.
Kumar, George L.; Kiernan, John A.; Gill, Gary W.; Badve, Sunil (2010). "Chapter 1: Introduction to special stains". Education guide: Special stains and H&E (2nd ed.
Layfield LJ, Bentz JS, Gopez EV. Immediate on-site interpretation of fine-needle aspiration smears: a cost and compensation analysis. Cancer. 2001;93:319-322.
Lester, S. C. (2019). "Section 2: Methods - Slide preparation". Diagnostic Pathology: Intraoperative Consultation (2nd ed.). Elsevier Health Sciences. p. 69. ISBN 978-0-323-57020-6.
Martin HE, Elis EB. Biopsy by needle puncture and aspiration. Ann Surg,1930;92:169-81.
McLaughlin JM, Anderson RT, Ferketich AK, Seiber EE, Balkrishnan R, Paskett ED. Effect on survival of longer intervals between confirmed diagnosis and treatment initiation among low-income women with breast cancer. J Clin Oncol. 2012;30(36):4493-500.
Meena, N; Jeffus, S; Massoll, N; Siegel, ER; Korourian, S; Chen, C; Bartter, T. Rapid Onsite Evaluation: A Comparison of Cytopathologist and Pulmonologist Performance. Cancer Cytopathology April 2016. p 279-284.
Mendoza P, Lacambra M, Tan P, et al. Fine needle aspiration cytology of the breast: the nonmalignant categories. Patholog Res Int 2011;2011:547580.
Miller DA, Carrasco CH, Katz RL, Cramer FM, Wallace S, Charnsangavej C. Fine needle aspiration biopsy: the role of immediate cytologic assessment. Am J Roentgenol 1986;147:155-8.
Nakano S, Otsuka M, Mibu A, Oinuma T (2015) Significance of fine needle aspiration cytology and vacuum-assisted core needle biopsy for small breast lesions. Clin Breast Cancer 15:23–26.
Nazário ACP, Rego MF, Oliveira VM. Nódulos benignos da mama: uma revisão dos diagnósticos diferenciais e conduta. Rev Bras Ginecol Obstet. 2007;29(4):211-20.
Nikhil M.; Jeffus, S; Massoll, N.; Siegel, E.R; Korourian, S.; Chen, C.; Bartter, T. Rapid Onsite Evaluation: A Comparison of Cytopathologist and Pulmonologist Performance. Cancer Cytopathology April 2016.
Oz A, Demirkazik F, Akpinar M, et al. Effi ciency of ultrasound and ultrasound-guided fi ne needle aspiration cytology in preoperative assessment of axillary lymph node metastases in breast cancer. J Breast Cancer 2012;15:211-7.
Part I: Semen analysis". WHO laboratory manual for the examination and processing of human semen (5th ed.). Geneva: World Health Organization. 2010. p. 62.
Pak HY, Yokota S, Teplitz RL, Shaw SL, Werner JL. Rapid staining techniques employed in fine needle aspirations of the lung. Acta Cito Cytol, 1981 25: 178-84.
Purasiri P, Abdalla M, Heys SD, Ah-See AK, McKean ME, Gilbert FJ, Needham G, Deans HE and Eremin O. A novel diagnostic index for use in the breast clinic. J R Coll Surg Edinb, 1996;41: 30-4.
Richard, D (2012). "Chapter 26: Stains". The art and science of cytopathology. Chicago, IL: Am Soc Clinical Pathology. p. 1505.
Richards MA, Westcombe AM, Love SB, Littlejohns P, Ramirez AJ. Influence of delay on survival in patients with breast cancer: a systematic review. Lancet. 1999;353(9159):1119-26.
Roh MH. The Utilization of Cytologic Fine-Needle Aspirates of Lung Cancer for Molecular Diagnostic Testing. Review Journal of Pathology and Translational Medicine 2015; 49(4): 300-309.
Saarela AO, Kiviniemi HO, Rissanen TJ, Paloneva TK. Nonpalpable breast lesions: Pathologic correlation of ultrasonographically guided fine-needle aspiration biopsy. J Ultrasound Med 1996;15:549–553.
Sartorius, O.W.; Smith, H.S.; Morris, P.; Benedict, D.; Friesen, L. Cytologic Evaluation of Breast Fluid in the Detection of Breast Disease. J NATL CANCER INST. VOL. 59, n. 4, 1977.
Schmidt RL, Witt BL, Lopez-Calderon LE, et al. The influence of rapid onsite evaluation on the adequacy rate of fine-needle aspiration cytology: a systematic review and meta-analysis. Am J Clin Pathol. 2013;139:300-308.
Sharma K, Costas A, Shulman LN, Meara JG. A systematic review of barriers to breast cancer care in developing countries resulting in delayed patient presentation. J Oncol. 2012;2012:121873.
Silverman JF, Frable WJ (1990). "The use of the diff-quik stain in the immediate interpretation of fine-needle aspiration biopsies". Diagnostic Cytopathology. 6 (5): 366–9.
Silverman JF, Finley JL, OBrien KF, et al. Diagnostic accuracy and role of immediate interpretation of fine needle aspiration biopsy specimens from various sites. Acta Cytol 1989;33:791-6.
SINGH T; CHANDRA K. Assessment of diagnostic accuracy of fine needle aspiration cytology in benign and Malignant breast lesions. International Journal of Medical and Biomedical Studies (IJMBS). Volume 4, Issue 3; March: 2020; Page No. 222-226.
Svante R. Orell, Gregory F. Sterett's Fine Needle Aspiration Cytology, 5th edition, Ch-7 "Breast". Elsevier Publications; 2012, 156-209.
Tfayli A, Temraz S, Abou Mrad R, Shamseddine A. Breast cancer in low- and middle-income countries: an emerging and challenging epidemic. J Oncol, 2010.
Trisolini R, Cancellieri A, Tinelli C, et al. Rapid on-site evaluation of transbronchial aspirates in the diagnosis of hilar and mediastinal adenopathy: a randomized trial. Chest. 2011;139:395-401.
Trufelli DC, Bensi CG, Pane CEV, Ramos E, Otsuda FC, Tannous NG, et al. Onde está o atraso? Avaliação do tempo necessário para o diagnóstico e tratamento do câncer de
Ukwenya AY, Yusufu LM, Nmadu PT, Garba ES, Ahmed A. Delayed treatment of symptomatic breast cancer: the experience from Kaduna, Nigeria. S Afr J Surg. 2008;46(4):106-10.
Trufelli DC, Bensi CG, Pane CEV, Ramos E, Otsuka FC, Tannous NG, et al. Onde está o atraso? Avaliação do tempo necessário para o diagnóstico e tratamento do câncer de mama nos serviços de oncologia da Faculdade de Medicina do ABC. Rev Bras Mastol.
;17(1):14-8.
William G. Finn; LoAnn C. Peterson (31 May 2004). "Role of fine needle aspiration in lymphoma". Hematopathology in Oncology. Springer Science & Business Media. p. 184.
with Breast Lesions. Folia Medica I 2018 I Vol. 60 I No. 3
Yarmus L, Van der Kloot T, Lechtzin N, et al. A randomized prospective trial of the utility of rapid on-site evaluation of transbronchial needle aspirate specimens. J Bronchology Interv Pulmonol. 2011;18:121-127.
