Associação entre obesidade e os níveis séricos de vitamina D / Association between obesity and serum vitamin D levels
DOI:
https://doi.org/10.34119/bjhrv5n3-120Keywords:
obesidade, vitamina d, dados antropométricos.Abstract
Introdução: A obesidade é caracterizada como um excesso de gordura corporal, com causa multifatorial relacionada ao sedentarismo e a questões poligenéticas e acomete 13% da parcela populacional adulta. A deficiência de vitamina D também é uma problemática mundial, sendo a realidade de cerca de 30 a 60% desta população. A relação entre a deficiência de vitamina D e a obesidade e os mecanismos fisiopatológicos subjacentes vem sendo alvo de maior investigação na literatura científica da última década. Objetivo: Avaliar a associação entre a obesidade e os níveis séricos de vitamina D. Métodos: Estudo clínico, transversal e do tipo survey, com coleta de dados em uma clínica no município de Aracaju-SE. O processo de coleta de dados foi dividido em 3 etapas e os dados obtidos foram compilados no programa Microsoft Office Excel versão 2016. Resultados: Foram avaliadas 76 pessoas com idade mínima de 19 anos e máxima de 85 anos, apresentando uma idade média de 41,3 anos. A maioria dos pacientes era do sexo feminino (69,7%). Verificou-se que a média de Índice de Massa Corpórea (IMC) foi de 28,6kg/m2, de circunferência da cintura de 92,5 cm, de circunferência do quadril de 104,0 cm e de relação cintura-quadril (RC/Q) foi 0,88. Conclusão: Houve correlação estatisticamente significativa entre os níveis de vitamina D e RC/Q com correlação de Spearman positiva. Já o peso, a circunferência da cintura e o IMC não tiveram uma associação estatisticamente significativa com a vitamina D sérica.
References
AATSINKI, Sanna-Mari et al. Fasting-induced transcription factors repress vitamin D bioactivation, a mechanism for vitamin D deficiency in diabetes. Diabetes, v. 68, n. 5, p. 918-931, 2019.
ABESO - Associação Brasileira para o Estudo da Obesidade e da Síndrome Metabólica. Diretrizes brasileiras de obesidade. 4.ed. São Paulo, 2016.
AQUINO, Séphora Louyse Silva et al. Effects of vitamin D supplementation on fasting glucose, dyslipidemia, blood pressure, and abdominal obesity among patients with metabolic syndrome: a protocol for systematic review and meta-analysis of randomized controlled trials. Systematic Reviews, v. 9, n. 1, p. 1-6, 2020.
ARONOW, Wilbert S. Association of obesity with hypertension. Annals of translational medicine, v. 5, n. 17, 2017.
BOUILLON, Roger. Extra-skeletal effects of vitamin D. Vitamin D in Clinical Medicine, v. 50, p. 72-88, 2018.
CAPRIO, Massimiliano et al. Vitamin D: not just the bone. Evidence for beneficial pleiotropic extraskeletal effects. Eating and Weight Disorders-Studies on Anorexia, Bulimia and Obesity, v. 22, n. 1, p. 27-41, 2017.
CHEN, Li-Wei et al. Low vitamin D level was associated with metabolic syndrome and high leptin level in subjects with nonalcoholic fatty liver disease: a community-based study. BMC gastroenterology, v. 19, n. 1, p. 1-8, 2019.
CHEN, Xi et al. Vitamin D receptor polymorphisms associated with susceptibility to obesity: A meta-analysis. Medical Science Monitor: International Medical Journal of Experimental and Clinical Research, v. 25, p. 8297, 2019.
CICERO, Arrigo FG; COLLETTI, Alessandro; BELLENTANI, Stefano. Nutraceutical approach to non-alcoholic fatty liver disease (NAFLD): the available clinical evidence. Nutrients, v. 10, n. 9, p. 1153, 2018.
DE OLIVEIRA, Lara Fonseca et al. Obesity and overweight decreases the effect of vitamin D supplementation in adults: systematic review and meta-analysis of randomized controlled trials. Reviews in Endocrine and Metabolic Disorders, v. 21, n. 1, p. 67-76, 2020.
DUAN, Leizhen et al. Effects of vitamin D supplementation on general and central obesity: results from 20 randomized controlled trials involving apparently healthy populations. Annals of Nutrition and Metabolism, v. 76, n. 3, p. 153-164, 2020.
DUTRA, Jeniffer Danielle Machado. Relação entre níveis séricos de vitamina D e doença hepática gordurosa não alcoólica. 2017.
ELKHWANKY, Mahmoud‐Sobhy et al. Obesity represses CYP2R1, the vitamin D 25‐hydroxylase, in the liver and extrahepatic tissues. JBMR plus, v. 4, n. 11, p. e10397, 2020.
FEGHALY, Julien; JOHNSON, Paul; KALHAN, Atul. Vitamin D and obesity in adults: a pathophysiological and clinical update. British Journal of Hospital Medicine, v. 81, n. 1, p. 1-5, 2020.
HAJHASHEMY, Zahra et al. Serum vitamin D levels in relation to abdominal obesity: A systematic review and dose–response meta‐analysis of epidemiologic studies. Obesity Reviews, v. 22, n. 2, p. e13134, 2021.
HAJHASHEMY, Zahra; FOSHATI, Sahar; SANEEI, Parvane. Relationship between abdominal obesity (based on waist circumference) and serum vitamin D levels: a systematic review and meta-analysis of epidemiologic studies. Nutrition reviews, v. 80, n. 5, p. 1105-1117, 2022.
KARAMPELA, Irene et al. Vitamin D and obesity: current evidence and controversies. Current obesity reports, v. 10, n. 2, p. 162-180, 2021.
NANSSEU, Jobert Richie; NOUBIAP, Jean Jacques; BIGNA, Jean Joel. Epidemiology of Overweight and Obesity in Adults Living in Cameroon: A Systematic Review and Meta‐Analysis. Obesity, v. 27, n. 10, p. 1682-1692, 2019.
PALANISWAMY, Saranya et al. Could vitamin D reduce obesity-associated inflammation? Observational and Mendelian randomization study. The American journal of clinical nutrition, v. 111, n. 5, p. 1036-1047, 2020.
PARK, Jung Eun; PICHIAH, PB Tirupathi; CHA, Youn-Soo. Vitamin D and metabolic diseases: growing roles of vitamin D. Journal of obesity & metabolic syndrome, v. 27, n. 4, p. 223, 2018.
PEREIRA, M. et al. Does vitamin D deficiency increase the risk of obesity in adults and the elderly? A systematic review of prospective cohort studies. Public Health, v. 190, p. 123-131, 2021.
ROIZEN, Jeffrey D. et al. Obesity decreases hepatic 25‐hydroxylase activity causing low serum 25‐hydroxyvitamin D. Journal of Bone and Mineral Research, v. 34, n. 6, p. 1068-1073, 2019.
RUIZ-OJEDA, Francisco Javier et al. Genetic factors and molecular mechanisms of vitamin D and obesity relationship. Annals of Nutrition and Metabolism, v. 73, p. 89-99, 2018.
SANGRÓS, F. J., et al. Association of general and abdominal obesity with hypertension, dyslipidemia and prediabetes in the predaps study. Rev Esp Cardiol (Engl Ed). 2018 Mar;71(3):170–7.
SERGEEV, Igor N. Vitamin D status and vitamin D-dependent apoptosis in obesity. Nutrients, v. 12, n. 5, p. 1392, 2020.
TRAISSAC, Pierre et al. Trends in Obesity, NHANES 2003-2004 to 2013-2014: Is Waist Circumference Increasing Independently of BMI?/Response. Obesity, v. 27, n. 7, p. 1043-1044, 2019.
VRANIĆ, Luka et al. Vitamin D deficiency: consequence or cause of obesity?. Medicina, v. 55, n. 9, p. 541, 2019.
WIMALAWANSA, Sunil J. Associations of vitamin D with insulin resistance, obesity, type 2 diabetes, and metabolic syndrome. The Journal of steroid biochemistry and molecular biology, v. 175, p. 177-189, 2018.
WU, Peter S. et al. Waist‐to‐hip ratio is a better predictor than body mass index for morbidity in abdominally based breast reconstruction. Microsurgery, v. 38, n. 7, p. 731-737, 2018.
YU, Songcheng et al. New evidence for associations between vitamin D receptor polymorphism and obesity: case-control and family-based studies. Journal of Human Genetics, v. 65, n. 3, p. 281-285, 2020.
ZHANG, Y. X., et al. The current prevalence and regional disparities in general and central obesity among children and adolescents in Shandong, China. Int J Cardiol. 2017 Jan;227:89–93.
