Uso da curcumina na terapia fotodinâmica antimicrobiana: uma revisão/ Use of curcumin in antimicrobial photodynamic therapy: a review
DOI:
https://doi.org/10.34119/bjhrv5n2-286Keywords:
curcumina, fotossensibilizador, terapia fotodinâmica antibacteriana.Abstract
A Terapia Fotodinâmica Antimicrobiana (TFDa) é uma modalidade terapêutica que tem apresentado ótimos resultados no tratamento de infecções em humanos e animais. Ela baseia-se na combinação tríplice entre um fotossensibilizador, luz e a presença de oxigênio molecular. A curcumina é um composto natural, extraído do rizoma da Curcuma longa, tem sido utilizada como fotossensibilizador em inúmeros trabalhos. Neste estudo realizou-se uma revisão da literatura buscando o uso da curcumina na TFDa. A busca foi realizada no banco de dados PubMed nos campos “título” e “resumo” no período de 2011 a 2020, utilizando as palavras-chave: “Curcumin” AND (“Photodynamic” OR “Photosensitve”) e (“Antimicrobial” OR “Antibacterial”). Foram encontrados 112 artigos científicos e 99 foram analisados. Destes, 87% são estudos in vitro utilizando mais de 15 gêneros de microorganismos, incluindo bactérias e fungos. Os estudos se concentraram principalmente na área odontológica, comprovando ser uma opção na eliminação dos microrganismos. O uso da Curcumina na TFDa demonstra ser uma alternativa promissora em superar as dificuldades no tratamento de infecções por bactérias multirresistentes.
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