Revisão de literatura: fatores de risco, fisiopatologia, diagnóstico e tratamento do trombo de ventrículo esquerdo / Literature review: risk factors, pathophysiology, diagnosis and treatment of left ventricle thrombus
DOI:
https://doi.org/10.34119/bjhrv5n2-215Keywords:
trombo, ventrículo esquerdo, tratamento, cardiologia.Abstract
Introdução: O trombo de ventrículo esquerdo (TVE) decorre de patologias como infarto agudo do miocárdio (IAM) e no tratamento são utilizados antagonistas da vitamina K (AVK) e novos anticoagulantes orais (NOACS). Objetivo: Analisar recomendações relacionadas ao tratamento do TVE, comparando fármacos e duração do tratamento. Métodos: Revisão integrativa de literatura realizada nas bases de dados LILACS e PubMED. Os descritores foram “left ventricular thrombus”, “treatment” e “anticoagulation” e os filtros “últimos 5 anos” e “texto gratuito”. Artigos não pertinentes foram excluídos, totalizando 14 analisados. Referências relevantes foram inseridas manualmente, assim como diretrizes de tratamento do TVE. Resultados: Os pilares para o tratamento do TVE são AVK e os NOACS. De acordo com a maioria das diretrizes, os AVK são as principais escolhas de tratamento, sendo os NOACS alternativas para casos especiais. Além disso, o tratamento deve ser iniciado imediatamente após o diagnóstico de TVE, com duração mínima de 3 meses.
References
BERRY, A.; BRANCHEAU, D.; ZUGHAIB, M. Rapid resolution of left ventricular thrombus with apixaban therapy. SAGE Open Medical Case Reports, v. 5, p. 2050313X1774521, 2017.
CRUZ RODRIGUEZ, J. B.; OKAJIMA, K.; GREENBERG, B. H. Management of left ventricular thrombus: a narrative review. Annals of Translational Medicine, v. 9, n. 6, p. 520–520, mar. 2021.
DALIA, T. et al. Warfarin versus direct oral anticoagulants for treating left ventricular thrombus: a systematic review and meta-analysis. Thrombosis Journal, v. 19, n. 1, p. 7, 1 dez. 2021.
DELEWI, R.; ZIJLSTRA, F.; PIEK, J. J. Left ventricular thrombus formation after acute myocardial infarction. Heart, v. 98, n. 23, p. 1743–1749, 14 dez. 2012.
GOTTDIENER, J. S. et al. Frequency and embolic potential of left ventricular thrombus in dilated cardiomyopathy: Assessment by 2-dimensional echocardiography. The American Journal of Cardiology, v. 52, n. 10, p. 1281–1285, dez. 1983.
GOTTDIENER, J. S. et al. Prevalence of left ventricular thrombus in dilated cardiomyopathy: The WATCH trial. Journal of the American College of Cardiology, v. 41, n. 6, p. 202, mar. 2003.
HABASH, F.; VALLURUPALLI, S. Challenges in management of left ventricular thrombus. Therapeutic Advances in Cardiovascular Disease, v. 11, n. 8, p. 203–213, 7 ago. 2017.
IBANEZ, B. et al. 2017 ESC Guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation. European Heart Journal, v. 39, n. 2, p. 119–177, 7 jan. 2018.
KAYA, A. et al. Resolution of left ventricular thrombus with apixaban in a patient with hypertrophic cardiomyopathy. Turk Kardiyoloji Dernegi Arsivi, v. 44, n. 4, p. 335–337, 2016.
KLEINDORFER, D. O. et al. 2021 Guideline for the Prevention of Stroke in Patients With Stroke and Transient Ischemic Attack: A Guideline From the American Heart Association/American Stroke Association. Stroke, v. 52, n. 7, jul. 2021.
KRISTENSEN, S. D.; LASSEN, J. F.; RAVN, H. B. Pathophysiology of coronary thrombosis. Seminars in Interventional Cardiology: SIIC. Anais...2000.
LATTUCA, B. et al. Antithrombotic Therapy for Patients With Left Ventricular Mural Thrombus. Journal of the American College of Cardiology, v. 75, n. 14, p. 1676–1685, 14 abr. 2020.
MACHADO GIL, V. Antagonistas da vitamina K todavia, ou nem por isso? Revista Portuguesa de Cardiologia, v. 35, n. 9, p. 467–468, set. 2016.
MANIWA, N. et al. Anticoagulation combined with antiplatelet therapy in patients with left ventricular thrombus after first acute myocardial infarction. European Heart Journal, v. 39, n. 3, p. 201–208, 14 jan. 2018.
MCCARTHY, C. P. et al. Left Ventricular Thrombus After Acute Myocardial Infarction. JAMA Cardiology, v. 3, n. 7, p. 642, 1 jul. 2018a.
MCCARTHY, C. P. et al. Left Ventricular Thrombus After Acute Myocardial Infarction. JAMA Cardiology, v. 3, n. 7, p. 642, 1 jul. 2018b.
MCCARTHY, C. P. et al. Left Ventricular Thrombus. Journal of the American College of Cardiology, v. 73, n. 15, p. 2007–2009, 23 abr. 2019.
MEURIN, P. et al. Incidence, diagnostic methods, and evolution of left ventricular thrombus in patients with anterior myocardial infarction and low left ventricular ejection fraction: a prospective multicenter study. American Heart Journal, v. 170, n. 2, p. 256–262, ago. 2015.
MOLLET, N. R. et al. Visualization of Ventricular Thrombi With Contrast-Enhanced Magnetic Resonance Imaging in Patients With Ischemic Heart Disease. Circulation, v. 106, n. 23, p. 2873–2876, 3 dez. 2002.
PIEGAS, L. et al. V DIRETRIZ DA SOCIEDADE BRASILEIRA DE CARDIOLOGIA SOBRE TRATAMENTO DO INFARTO AGUDO DO MIOCÁRDIO COM SUPRADESNÍVEL DO SEGMENTO ST. Arquivos Brasileiros de Cardiologia, v. 105, n. 2, 2015.
ROBINSON, A. A. et al. Left ventricular thrombi after STEMI in the primary PCI era: A systematic review and meta-analysis. International Journal of Cardiology, v. 221, p. 554–559, 2016.
RODRIGUES, B. V. P. C. et al. As Indicações E Os Efeitos Adversos Dos Novos Anticoagulantes Orais Utilizados Na the Indications and Adverse Effects of the New Oral Anticoagulants Used in Clinical Practice. v. 33, p. 54–63, 2021.
ROIFMAN, I. et al. Echocardiography vs Cardiac Magnetic Resonance Imaging for the Diagnosis of Left Ventricular Thrombus: A Systematic Review. Canadian Journal of Cardiology, v. 31, n. 6, p. 785–791, jun. 2015.
SALEIRO, C. et al. Left Ventricular Thrombus Therapy With Direct Oral Anticoagulants Versus Vitamin K Antagonists: A Systematic Review and Meta-Analysis. Journal of Cardiovascular Pharmacology and Therapeutics, 2020.
SCHVARTZMAN, PAULO R. SOCIEDADE de CARDIOLOGIA do RIO GRANDE DO SUL ** Doutorando da Pontifícia Universidade Católica do Rio Grande do Sul. p. 1–5, 2004.
SILVESTRE, J. M. DA S. et al. Necrose cutânea induzida por antagonistas da vitamina K. Jornal Vascular Brasileiro, v. 8, n. 4, p. 343–348, dez. 2009.
SPADACCIO, C.; BENEDETTO, U. Coronary artery bypass grafting (CABG) vs. percutaneous coronary intervention (PCI) in the treatment of multivessel coronary disease: quo vadis? —a review of the evidences on coronary artery disease. Annals of Cardiothoracic Surgery, v. 7, n. 4, p. 506–515, jul. 2018.
STEIN, B.; FUSTER, V. Antithrombotic therapy in acute myocardial infarction: Prevention of venous, left ventricular and coronary artery thromboembolism. The American Journal of Cardiology, v. 64, n. 4, p. 33B-40B, jul. 1989.
SÜRDER, D. et al. Thrombus formation in the left ventricle after large myocardial infarction – assessment with cardiac magnetic resonance imaging. Swiss Medical Weekly, 22 jun. 2015.
WEINSAFT, J. W. et al. Detection of Left Ventricular Thrombus by Delayed-Enhancement Cardiovascular Magnetic Resonance. Journal of the American College of Cardiology, v. 52, n. 2, p. 148–157, jul. 2008.


