Probióticos no tratamento da depressão: uma revisão sistemática / Probiotics in the treatment of depression: a systematic review
DOI:
https://doi.org/10.34119/bjhrv5n1-163Keywords:
Depressão, eixo cérebro-intestino, probióticos.Abstract
Este estudo teve por objetivo analisar a relação entre o eixo cérebro intestino em indivíduos depressivos e a ação dos probióticos na melhoria dos sintomas. Foi utilizada a base de dados PUBMED, onde foram encontrados 90 estudos, seguindo os critérios de inclusão e exclusão, resultaram-se 10 artigos de ensaio clínico no período de 2014 a 2019. Dos 10 estudos, nove estudos apresentaram resultados positivos. Observou-se que a suplementação de probióticos atenuou a sintomatologia da depressão no qual reduziu o estresse, a expressão do gene IL-6, a ansiedade e aumentou a expressão do gene IL-17 e o Fator Neurotrófico Derivado do Cérebro (BDNF). Verificou-se que a modulação da microbiota intestinal, através da ingestão de probióticos interfere no eixo intestino-cérebro causada pelos sintomas de depressão. Contudo, mais estudos são precisos sobre esse assunto.
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