Drug therapy and vascular devices used by patients hospitalized for COVID-19: a descriptive study / Terapia medicamentosa e dispositivos vasculares utilizados por doentes hospitalizados para a COVID-19: um estudo descritivo

Authors

  • Helena Ferraz Gomes Brazilian Journals Publicações de Periódicos, São José dos Pinhais, Paraná
  • Bruna Maiara Ferreira Barreto Pires
  • Priscila Cristina da Silva Thiengo Andrade
  • Antonio Marcos Tosoli Gomes
  • Norma Valéria Dantas de Oliveira Souza
  • Eloá Carneiro Carvalho
  • Thais Mayerhofer Kubota
  • Cristiene Faria
  • Dayana Carvalho Leite
  • André Herdy Afonso Alves de Lima
  • José Augusto Messias
  • Monique Barreto Santana
  • Denilson Campos de Albuquerque
  • Denize Cristina Oliveira
  • Mauricio Cupello Peixoto
  • Pedro de Jesus Silva
  • Lilian Prates Belem Behring
  • Livia Fajin de Mello
  • Carolina Cabral Pereira da Costa
  • Magno Conceição das Merces
  • Luana Ferreira de Almeida
  • Vanessa Galdino de Paula
  • Morena Peres Bittencourt
  • Brenda Gratielle Oliveira
  • Vitoria Rocha dos Santos
  • Ellen Marcia Peres

DOI:

https://doi.org/10.34119/bjhrv4n6-360

Keywords:

Coronavirus Infections, Pharmaceutical Preparations, Peripheral Catheterization, Central Venous Catheterization, COVID-19.

Abstract

To describe drug therapy and types of vascular access adopted in the treatment of patients with COVID-19 and admitted to the clinical wards of a university hospital, a referential institution for COVID-19 in Rio de Janeiro, Brazil. Descriptive, retrospective documentary study with a quantitative approach. The sample consisted of 243 electronic medical records from hospitalized patients with a laboratory-confirmed diagnosis of COVID-19, between April and June 2020. The selection of participants took place by intentional non-probabilistic sampling. Peripheral venous access was the mostly applied in 83.5% of the patients. The mostly used classes of drugs were analgesics, (81.9%), followed by antiemetics (70.4%), and antihypertensives (51.9%). For medications directed to COVID-19, azithromycin, oseltamivir, ceftriaxone, and hydroxychloroquine stands out with 67.5%, 58.8%, 50.2% and 27.2%, respectively.  Regarding the treatment directed to COVID-19, the medications mostly taken were azithromycin and hydroxychloroquine, justified to a large extent by being recommended by the Ministry of Health in the treatment, according to signs and symptoms (Brazil, 2020).  Patients treated with the medications described had good recovery from the clinical condition. Thus, studies based on randomized clinical trials are suggested to prove the efficacy of drug therapies, including their combination.

References

Brazil. Ministery of Health. COVID-19 clinical management protocol in specialized care. Brazilian; 2020. Accessed February 23, 2021.

https://bvsms.saude.gov.br/bvs/publicacoes/manejo_clinico_covid-19_atencao_especializada.pdf

Brazil. Ministery of Health. Guidelines for early drug handling of patients diagnosed with COVID-19. Brazilian; 2020. Accessed February 23, 2021.

https://www.gov.br/saude/pt-br/media/pdf/2021/marco/08/covid-05mar2021-11h37.pdf

Food and Drug Administration. Investigational-covid-19-convalescent-plasma-emergency-inds. US Food and Drug Administration. USA: Food and Drug Administration; 2020. Accessed February 23, 2021.

https://www.fda.gov/vaccines-bloodbiologics/investigational-new-drug-ind-or-device-exemption-ide-processcber/investigational-covid-19-convalescent-plasma-emergency-inds.

Palmeira VA, Costa LB, Perez LG, Ribeiro VT, Lanza K, Silvia ACS. Do we have enough evidence to use chloroquine/hydroxychlooquine as a public health panacea for COVID-19? Clinics. 2020;75: e1928. doi: 10.6061/clinics/2020/e1928

Hernandez AV, Roman YM, Pasupuleti V, Barboza JJ, White CM. Hydroxychloroquine or Chloroquine for Treatment or Prophylaxis of COVID-19: A Living Systematic Review. Annals of Internal Medicine. 2020;173(4):287-296. doi: 10.7326/M20-2496

Geleris J, Sun Y, Platt J, et al. Observational Study of Hydroxychloroquine in Hospitalized Patients with Covid-19. N Engl J Med. 2020;382(25):2411-2418. doi: 10.1056/NEJMoa2012410

Infusion Nurses Society (INS). Infusion therapy standards of practice. Journal of Intravenous Nursing. 2016;39(1S): S1-S165. Accessed February 18, 2021.

http://source.yiboshi.com/20170417/1492425631944540325.pdf

Brazilian Intensive Care Association - Associação de Medicina Intensiva Brasileira (AMIB). Recommendations of the Brazilian Intensive Care Association for the approach of COVID-19 in intensive care. 2020. Accessed February 26, 2021. https://www.amib.org.br/fileadmin/user_upload/amib/2020/abril/04/Recomendacoes_AMIB04042020_10h19.pdf Original Work Published in Portuguese.

Colaneri M, Sacchi P, Zuccaro V, et al. Clinical Characteristics of coronavirus disease (COVID-19) early findings from a teaching hospital in Pavia, North Italy, 21 to February 2020. Euro Suveril. 2020;25(16):2000460. Accessed February 26, 2021.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7189652/

Gao C, Cai Y, Zhang K, et al. Association of hypertension and antihypertensive treatment with COVID-19 mortality: a retrospective observational study. Eur Heart J. 2020;41 (22):2058-2066. doi: 10.1093/eurheartj/ehaa433

Liang X, Shi L, Wang Y, et al. The association of hypertension with the severity and mortality of COVID-19 patients: Evidence based on adjusted effect estimates. J Infect. 2020;81(3):e44-e47. doi: 10.1016/j.jinf.2020.06.060

Richardson S, Hirsc JS, Narasimhan M, Crawford JM, McGinn T, Davidson KW. Presenting characteristics, comorbities and outcomes among 5700 patients hospitalized with COVID-19 in the New York City Area. JAMA. 2020;323(20):2052-2059. doi: 10.1001/jama.2020.6775

DiNicolantonio JJ, Barroso-Aranda J, McCarty MF. Azithromycin and glucosamine may amplify the type 1 interferon response to RNA viruses in a complementary fashion. Immunology Letters. 2020;228: 83–85. doi: 10.1016/j.imlet.2020.09.008

Melanie B, Paparone P, Kim AM, Mutalik S, Ernst CL. Psychopharmacology of COVID-19. Psychosomatics. 2020;61(5):411–427. doi: 10.1016/j.psym.2020.05.006

Sahraei Z, Shabani M, Shokouhi S, Saffaei A. Aminoquinolines against coronavirus disease 2019 (COVID-19): chloroquine or hydroxychloroquine. Int J Antimicrob Agents. 2020;55(4):105945. doi: 10.1016/j.ijantimicag.2020.105945

Rosenberg ES, Dufort EMUdoT, Wilberschied LA, et al. Association of Treatment With Hydroxychloroquine or Azithromycin With In-Hospital Mortality in Patients With COVID-19 in New York State. JAMA. 2020;323(24):2493–2502. doi: 10.1001/jama.2020.8630

Yazdany J, Kim AHJ. Use of Hydroxychloroquine and Chloroquine During the COVID-19 Pandemic: What Every Clinician Should Know. Ann Intern Med. 2020;172(11):754-755. doi: 10.7326/M20-1334

Wang D, Hu B, Hu C, et al. Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, China. JAMA. 2020;323(11):1061-1069. doi: 10.1001/jama.2020.1585

Dobson J, Whitley RJ, Pocock S, Monto AS. Oseltamivir treatment for influenza in adults: a meta-analysis of randomized controlled trials. The Lancet. 2015;385:1729-1737. doi: 10.1016/S0140-6736(14)62449-1

Zhou F, Yu T, Du R, et al. Clinical course and risk factors for mortality of adult in patients with COVID-19 in Wuhan, China: a retrospective cohort study. The Lancet. 2020;395(10229):1054-1062. doi: 10.1016/S0140-6736(20)30566-3

Susen S, Tacquard CA, Godon A, et al. Prevention of thrombotic risk in hospitalized patients with COVID-19 and hemostasis monitoring. Crit Care. 2020;24(1):364. doi: 10.1186/s13054-020-03000-7

Tang N, Li D, Wang X, Sun Z . Abnormal coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia. J Thromb Haemost. 2020;18(4):844-847. doi: 10.1111/jth.14768

Huang R, Zhu L, Xue L, et al. Clinical findings of patients with coronavirus disease 2019 in Jiangsu province, China: a retrospective, multi-center study. PLoS Negl Trop Dis. 2020;14(5):e0008280. doi: 10.1371/journal.pntd.0008280

Omidi N, Forouzannia SK, Poorhosseini H, Tafti SHA, Salehbeigi S, Lofti-Tokaldani M. Prosthetic heart valves and the COVID-19 pandemic era: What should we be concerned about? Journal of Cardiac Surgery. 2020;35:2500-2505. doi: 10.1111/jocs.14707

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Published

2021-12-17

How to Cite

GOMES, H. F.; PIRES, B. M. F. B.; ANDRADE, P. C. da S. T.; GOMES, A. M. T.; SOUZA, N. V. D. de O.; CARVALHO, E. C.; KUBOTA, T. M.; FARIA, C.; LEITE, D. C.; DE LIMA, A. H. A. A.; MESSIAS, J. A.; SANTANA, M. B.; DE ALBUQUERQUE, D. C.; OLIVEIRA, D. C.; PEIXOTO, M. C.; SILVA, P. de J.; BEHRING, L. P. B.; DE MELLO, L. F.; DA COSTA, C. C. P.; DAS MERCES, M. C.; DE ALMEIDA, L. F.; DE PAULA, V. G.; BITTENCOURT, M. P.; OLIVEIRA, B. G.; DOS SANTOS, V. R.; PERES, E. M. Drug therapy and vascular devices used by patients hospitalized for COVID-19: a descriptive study / Terapia medicamentosa e dispositivos vasculares utilizados por doentes hospitalizados para a COVID-19: um estudo descritivo. Brazilian Journal of Health Review, [S. l.], v. 4, n. 6, p. 28093–28104, 2021. DOI: 10.34119/bjhrv4n6-360. Disponível em: https://ojs.brazilianjournals.com.br/ojs/index.php/BJHR/article/view/41501. Acesso em: 28 apr. 2024.

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Original Papers