Lipidômica no câncer de colorretal: uma revisão na literatura recente / Lipidomic of colorrectal cancer: a recent review
DOI:
https://doi.org/10.34119/bjhrv4n5-400Keywords:
“CRC”, “colorrectal cancer”, “lipidomics”, “biomarkers”Abstract
O câncer de colorretal (CCR) é a terceira causa de câncer mais comum no mundo, tendo bom prognóstico quando detectado precocemente e abordado, porém a forma como o screening é realizado hoje, por meio de exames pouco sensíveis e específicos, torna-se de suma importância a procura por novos biomarcadores. Dessa forma, a lipidômica é uma área que provê perspectivas promissoras, visto que os lipídios participam de processos intimamente conectados à carcinogênese. Este estudo visa elencar novos lipídios como potenciais biomarcadores. É um estudo de revisão, buscando artigos publicados nos últimos 5 anos, na plataforma pubmed. Dentre os lipídios citados nos estudos as classes de LPC, GP e PK merecem um estudo mais específico, visto que são classes citadas em mais de um estudo como possíveis biomarcadores. Os artigos publicados entre 2017-2021 tiveram uma abordagem inicial na procura por marcadores, portanto foram elencadas algumas proteínas, porém deve-se desenvolver novas pesquisas para estudar comportamento desses potenciais biomarcadores e sua aplicação na prática médica.
References
Donato P, Cacciola F, Beccaria M, Dugo P, Mondello L. Lipidomics. In ‘Comprehensive Analytical Chemistry’, Ed Pico? Y . Advanced mass spectrometry for food safety and quality. Elsevier Press, Oxford, pp 395-439; 2015
Li M, Yang L, Bai Y, et al. Analytical methods in lipidomics and their applications. Anal Chem. 2014; 86, 161-75.
Perrotti F, Rosa C, Cicalini I, Sacchetta P, Del Boccio P, Genovesi D, Pieragostino D. Advances in Lipidomics for Cancer Biomarkers Discovery. Int J Mol Sci. 2016;17(12).
Notarnicola M, Messa C, Caruso MG, A significant role of lipogenic enzymes in colorectal cancer, Anticancer Res. 32 .2012; 2585–2590.
Zaytseva. YY, Harris JW, Mitov MI, Kim JT, Butterfield DA, Lee EY, Weiss. HL, Gao T, Evers BM, Increased expression of fatty acid synthase provides a survival
advantage to colorectal cancer cells via upregulation of cellular respiration, Oncotarget. 6 .2015; 18891– 18904.
Satoh K, Yachida S, Sugimoto M, Oshima M, Nakagawa T, Akamoto S, Tabata S, Saitoh K, Kato K, Sato S, Igarashi K, Aizawa Y, Kajino-Sakamoto R, Kojima Y, Fujishita T, Enomoto A, Hirayama A, Ishikawa T, Taketo MM, Kushida Y, Haba R, Okano K, Tomita M, Suzuki Y, Fukuda S, Aoki M, Soga T, Global metabolic reprogramming of colorectal cancer occurs at adenoma stage and is induced by MYC, Proc. Natl. Acad. Sci. U. S. A. 114 .2017; E7697–E7706.
Mika A, Kobiela J, Czumaj A, Chmielewski M, Stepnowski P, Sledzinski T, Hyper- elongation in colorectal cancer tissue - cerotic acid is a potential novel serum metabolic marker of colorectal malignancies, Cell. Physiol. Biochem. 41
.2017; 722–730.
Gong J, Lin Y, Zhang H, Liu C, Cheng Z, Yang X, Zhang J, Xiao Y, Sang N, Qian X, Wang L, Cen X, Du X, Zhao Y. Reprogramming of lipid metabolism in cancer-associated fibroblasts potentiates migration of colorectal cancer cells. Cell Death Dis. 2020; doi: 10.1038/s41419-020-2434-z. PMID: 32327627; PMCID: PMC7181758.
Serafim Patricia Valeria Pereira, Figueiredo Adiel Goes de, Felipe Aledson Vitor, Lo Turco Edson Guimaraes, da Silva Ismael Dale Cotrim Guerreiro, Forones Nora Manoukian. STUDY OF LIPID BIOMARKERS OF PATIENTS WITH POLYPS AND COLORECTAL CÂNCER. Arquivos de Gastroenterologia. 2019; 10.1590/S0004-2803.201900000-80
de Figueiredo Junior AG, Serafim PVP, de Melo AA, et al. Analysis of the Lipid Profile in Patients with Colorectal Cancer in Advanced Stages. Asian Pac J Cancer Prev. 2018;19(5):1287-1293. Published 2018 May 26. doi:10.22034/APJCP.2018.19.5.1287
Wang, Y., Hinz, S., Uckermann, O., Hönscheid, P., von Schönfels, W., Burmeister, G., Hendricks, A., Ackerman, J. Miranda, Baretton, G. B, Hampe, J., Brosch, M., Schafmayer, C., Shevchenko, A., & Zeissig, S. (2020). Shotgun lipidomics-based characterization of the landscape of lipid metabolism in
colorectal cancer. Biochimica et biophysica acta, 1865, . doi: 10.1016/j.bbalip.2019.158579
sus+ MINISTÉRIO DA SAÚDE Age?ncia Brasileira do ISBN [Internet]. Available from:
https://www.inca.gov.br/sites/ufu.sti.inca.local/files//media/document//estimativa
-incidencia-de- cancer-no-brasil-2020.pdf
Arvelo F, Sojo F, Cotte C. Biology of colorectal cancer. Available from: www.ecancer.org
Fearon ER, Vogelstein B. A genetic model for colorectal tumorigenesis. Cell [Internet]. 1990 Jun 1;61(5):759–67. Available from: http://www.ncbi.nlm.nih.gov/pubmed/2188735
Ang CS, Baker MS, Nice EC. Mass Spectrometry-Based Analysis for the Discovery and Validation of Potential Colorectal Cancer Stool Biomarkers [Internet]. In: Methods in enzymology. 2017. p. 247–274.Available from: http://www.ncbi.nlm.nih.gov/pubmed/28137566
Rutka M, Bor R, Ba?lint A, Fa?bia?n A, Milassin Á, Nagy F, et al. Diagnostic Accuracy of Five Different Fecal Markers for the Detection of Precancerous and Cancerous Lesions of the Colorectum. Mediators Inflamm. [Internet]. 2016 Jun 16; 2016:1–6. Available from: http://www.hindawi.com/journals/mi/2016/2492081/
Rutka M, Bor R, Ba?lint A, Fa?bia?n A, Milassin Á, Nagy F, et al. Diagnostic Accuracy of Five Different Fecal Markers for the Detection of Precancerous and Cancerous Lesions of the Colorectum. Mediators Inflamm. [Internet]. 2016 Jun 16;2016:1–6. Available from: http://www.hindawi.com/journals/mi/2016/2492081/
Brenner H, Chang-Claude J, Seiler CM, Rickert A, Hoffmeister M. Protection From Colorectal Cancer After Colonoscopy. Ann. Intern. Med. [Internet]. 2011 Jan 4 ;154(1):22. Available from: http://www.ncbi.nlm.nih.gov/pubmed/21200035/
DeSantis CECCE, Lin CCCCCCC, Mariotto AAB, Siegel RRLRRL, Stein KDKKD, Kramer JJL, et al. Cancer treatment and survivorship statistics, 2014. CA. Cancer J. Clin. 2014;
Wang K, Huang C, Nice EC. Proteomics, genomics and transcriptomics: their emerging roles in the discovery and validation of colorectal cancer biomarkers. Expert Rev. Proteomics [Internet]. 2014;11(2):179–205. Available from: http://www.ncbi.nlm.nih.gov/pubmed/24611605
Zauber AG, Winawer SJ, O’Brien MJ, Lansdorp-Vogelaar I, van Ballegooijen M, Hankey BF, et al. Colonoscopic Polypectomy and Long-Term Prevention of Colorectal-Cancer Deaths. N. Engl. J. Med. [Internet]. 2012 Feb 23;366(8):687– 696. Available from: http://www.nejm.org/doi/abs/10.1056/NEJMoa1100370
Liang PS, Dominitz JA. Colorectal Cancer Screening. Med. Clin. North Am. [Internet]. 2019 Jan;103(1):111–123. Available from: https://linkinghub.elsevier.com/retrieve/pii/S0025712518301019
Wolf AMD, Fontham ETH, Church TR, Flowers CR, Guerra CE, LaMonte SJ, et al. Colorectal cancer screening for average-risk adults: 2018 guideline update from the American Cancer Society. CA. Cancer J. Clin. [Internet]. 2018 Jul 30;68(4):250–281. Available from: http://www.ncbi.nlm.nih.gov/pubmed/29846947/
Bailey JR, Aggarwal A, Imperiale TF. Colorectal Cancer Screening: Stool DNA and Other Noninvasive Modalities. Gut Liver [Internet]. 2016 Mar;10(2):204. Available from: http://www.ncbi.nlm.nih.gov/pubmed/26934885
McLachlan S-A, Clements A, Austoker J. Patients’ experiences and reported barriers to colonoscopy in the screening context—A systematic review of the literature. Patient Educ. Couns. [Internet]. 2012 Feb;86(2):137–146. Available from: https://linkinghub.elsevier.com/retrieve/pii/S0738399111001984
Navarro M, Nicolas A, Ferrandez A, Lanas A. Colorectal cancer population screening programs worldwide in 2016: An update. World J. Gastroenterol. [Internet]. 2017;23(20):3632. Available from: http://www.wjgnet.com/1007- 9327/full/v23/i20/3632.htm
Kos?cielniak-Merak B, Radosavljevic? B, Zaja?c A, Tomasik PJ. Faecal Occult Blood Point-of-Care Tests. J. Gastrointest. Cancer [Internet]. 2018 Dec 20;49(4):402–405. Available from: http://link.springer.com/10.1007/s12029-018- 0169-1
Issa IA, Noureddine M. Colorectal cancer screening: An updated review of the available options. World J. Gastroenterol. [Internet]. 2017 [;23(28):5086. Available from: http://www.wjgnet.com/1007-9327/full/v23/i28/5086.htm
Gonzalez-Pons M, Cruz-Correa M. Colorectal Cancer Biomarkers: Where Are We Now? Biomed Res. Int. [Internet]. 2015;2015:1–14. Available from: http://www.hindawi.com/journals/bmri/2015/149014/
Alnabulsi A, Murray GI. Integrative analysis of the colorectal cancer proteome: potential clinical impact. Expert Rev. Proteomics [Internet]. 2016 Oct 2 ;13(10):917–927. Available from: https://www.tandfonline.com/doi/full/10.1080/14789450.2016.1233062
Chauvin A, Boisvert F-M. Clinical Proteomics in Colorectal Cancer, a Promising Tool for Improving Personalised Medicine. Proteomes [Internet]. 2018 Dec 2;6(4):49. Available from: http://www.mdpi.com/2227-7382/6/4/49
Perrotti F, Rosa C, Cicalini I, Sacchetta P, Del Boccio P, Genovesi D, Pieragostino D.Advances in Lipidomics for Cancer Biomarkers Discovery. Int J Mol Sci. 2016;17(12).
Mika A, Kobiela J, Czumaj A, Chmielewski M, Stepnowski P, Sledzinski T. Hyper-Elongation in Colorectal Cancer Tissue - Cerotic Acid is a Potential Novel Serum Metabolic Marker of Colorectal Malignancies. Cell Physiol Biochem. 2017;41(2):722-730. doi:10.11
