Covid-19, Doença de Kawasaki e Síndrome Inflamatória Multissistêmica: semelhanças e peculiaridades clínicas, uma Revisão de Literatura / Covid-19, Kawasaki Disease and Multisystem Inflammatory Syndrome: clinical similarities and peculiarities, a Review
DOI:
https://doi.org/10.34119/bjhrv4n4-197Keywords:
Covid-19, Doença de Kawasaki, Síndrome Inflamatória Multissistêmica em Crianças.Abstract
A Covid-19 é uma doença causada pelo vírus Sars-CoV-2, descrita pela primeira vez em dezembro de 2019, com uma menor prevalência observada na população pediátrica em relação à população adulta. Entretanto, recentemente tem sido relatada uma síndrome que apresenta similaridades com a Doença de Kawasaki, acometendo essa faixa etária, relacionada temporalmente a infecção pelo SarS-CoV-2, denominada Síndrome Inflamatória Multissistêmica em Crianças (MIS-C) Kawasaki-like. O objetivo deste artigo é facilitar a suspeição e o reconhecimento dessa nosologia pelo profissional assistente.
References
: Kabeerdoss J, Pilania RK, Karkhele R, Kumar TS, Danda D, Singh S. Severe COVID-19, multisystem inflammatory syndrome in children, and Kawasaki disease: immunological mechanisms, clinical manifestations and management. Rheumatol Int. 2021 Jan;41(1):19-32. doi: 10.1007/s00296-020-04749-4. Epub 2020 Nov 21. PMID: 33219837; PMCID: PMC7680080.
: Iranmanesh B, Khalili M, Amiri R, Zartab H, Aflatoonian M. Oral manifestations of COVID-19 disease: A review article. Dermatol Ther. 2021 Jan;34(1):e14578. doi: 10.1111/dth.14578. Epub 2020 Dec 13. PMID: 33236823; PMCID: PMC7744903.
: Chang WT, Toh HS, Liao CT, Yu WL. Cardiac Involvement of COVID-19: A Comprehensive Review. Am J Med Sci. 2021 Jan;361(1):14-22. doi: 10.1016/j.amjms.2020.10.002. Epub 2020 Oct 6. PMID: 33187633; PMCID: PMC7536131.
: Sperotto F, Friedman KG, Son MBF, VanderPluym CJ, Newburger JW, Dionne A. Cardiac manifestations in SARS-CoV-2-associated multisystem inflammatory syndrome in children: a comprehensive review and proposed clinical approach. Eur J Pediatr. 2021 Feb;180(2):307-322. doi: 10.1007/s00431-020-03766-6. Epub 2020 Aug 15. PMID: 32803422; PMCID: PMC7429125.
: Harwood R, Allin B, Jones CE, Whittaker E, Ramnarayan P, Ramanan AV, Kaleem M, Tulloh R, Peters MJ, Almond S, Davis PJ, Levin M, Tometzki A, Faust SN, Knight M, Kenny S; PIMS-TS National Consensus Management Study Group. A national consensus management pathway for paediatric inflammatory multisystem syndrome temporally associated with COVID-19 (PIMS-TS): results of a national Delphi process. Lancet Child Adolesc Health. 2021 Feb;5(2):133-141. doi: 10.1016/S2352-4642(20)30304-7. Epub 2020 Sep 18. Erratum in: Lancet Child Adolesc Health. 2021 Feb;5(2):e5. PMID: 32956615; PMCID: PMC7500943.
: Andina D, Belloni-Fortina A, Bodemer C, Bonifazi E, Chiriac A, Colmenero I, Diociaiuti A, El-Hachem M, Fertitta L, van Gysel D, Hernández-Martín A, Hubiche T, Luca C, Martos-Cabrera L, Maruani A, Mazzotta F, Akkaya AD, Casals M, Ferrando J, Grimalt R, Grozdev I, Kinsler V, Morren MA, Munisami M, Nanda A, Novoa MP, Ott H, Pasmans S, Salavastru C, Zawar V, Torrelo A; ESPD Group for the Skin Manifestations of COVID-19. Skin manifestations of COVID-19 in children: Part 3. Clin Exp Dermatol. 2021 Apr;46(3):462-472. doi: 10.1111/ced.14483. Epub 2020 Nov 18. PMID: 33207021; PMCID: PMC7753282.
: Pérez-Bartolomé F, Sánchez-Quirós J. Ocular manifestations of SARS-CoV-2: Literature review. Arch Soc Esp Oftalmol (Engl Ed). 2021 Jan;96(1):32-40. English, Spanish. doi: 10.1016/j.oftal.2020.07.020. Epub 2020 Aug 8. PMID: 32873480; PMCID: PMC7414418.
: Pousa PA, Mendonça TSC, Oliveira EA, Simões-E-Silva AC. Extrapulmonary manifestations of COVID-19 in children: a comprehensive review and pathophysiological considerations. J Pediatr (Rio J). 2021 Mar- Apr;97(2):116-139. doi: 10.1016/j.jped.2020.08.007. Epub 2020 Sep 22. PMID: 32980319; PMCID: PMC7508521.
: Niaz T, Hope K, Fremed M, Misra N, Altman C, Glickstein J, Sanchez-de-Toledo J, Fraisse A, Miller J, Snyder C, Johnson JN, Chowdhury D. Role of a Pediatric Cardiologist in the COVID-19 Pandemic. Pediatr Cardiol. 2021 Jan;42(1):19-35. doi: 10.1007/s00246-020-02476-y. Epub 2020 Oct 4. PMID: 33015722; PMCID: PMC7533115.
: Simon Junior H, Sakano TMS, Rodrigues RM, Eisencraft AP, Carvalho VEL, Schvartsman C, Reis AGADC. Multisystem inflammatory syndrome associated with COVID-19 from the pediatric emergency physician's point of view. J Pediatr (Rio J). 2021 Mar-Apr;97(2):140-159. doi: 10.1016/j.jped.2020.08.004. Epub 2020 Sep 11. PMID: 32946801; PMCID: PMC7486073.
: Kurz DJ, Eberli FR. Cardiovascular aspects of COVID-19. Swiss Med Wkly. 2020 Dec 31;150:w20417. doi: 10.4414/smw.2020.20417. PMID: 33382450.
: Khalili M, Iranmanesh B, Mohammadi S, Aflatoonian M. Cutaneous and histopathological features of coronavirus disease 2019 in pediatrics: A review article. Dermatol Ther. 2021 Jan;34(1):e14554. doi: 10.1111/dth.14554. Epub 2020 Dec 8. PMID: 33210417; PMCID: PMC7744858.
: Henderson LA, Yeung RSM. MIS-C: early lessons from immune profiling. Nat Rev Rheumatol. 2021 Feb;17(2):75-76. doi: 10.1038/s41584-020-00566-y. PMID: 33349661; PMCID: PMC7750910.
: Capocasale G, Nocini R, Faccioni P, Donadello D, Bertossi D, Albanese M, Zotti F. How to deal with coronavirus disease 2019: A comprehensive narrative review about oral involvement of the disease. Clin Exp Dent Res. 2021 Feb;7(1):101-108. doi: 10.1002/cre2.332. Epub 2020 Oct 5. PMID: 33021087; PMCID: PMC7675550.
: Maxwell AJ, Ding J, You Y, Dong Z, Chehade H, Alvero A, Mor Y, Draghici S, Mor G. Identification of key signaling pathways induced by SARS-CoV2 that underlie thrombosis and vascular injury in COVID-19 patients. J Leukoc Biol. 2021 Jan;109(1):35-47. doi: 10.1002/JLB.4COVR0920-552RR. Epub 2020 Nov 26. PMID: 33242368; PMCID: PMC7753679.
: Islam MN, Hossain KS, Sarker PP, Ferdous J, Hannan MA, Rahman MM, Chu DT, Uddin MJ. Revisiting pharmacological potentials of Nigella sativa seed: A promising option for COVID-19 prevention and cure. Phytother Res. 2021 Mar;35(3):1329-1344. doi: 10.1002/ptr.6895. Epub 2020 Oct 12. PMID: 33047412; PMCID: PMC7675410.
: Szarpak L, Filipiak KJ, Gasecka A, Pruc M, Drozd A, Jaguszewski MJ. Correlation between takotsubo cardiomyopathy and SARS-CoV-2 infection. Med Hypotheses. 2021 Jan;146:110454. doi: 10.1016/j.mehy.2020.110454. Epub 2020 Dec 9. PMID: 33338954; PMCID: PMC7724514.
: Zhang RL, Lo HH, Lei C, Ip N, Chen J, Law BY. Current pharmacological intervention and development of targeting IVIG resistance in Kawasaki disease. Curr Opin Pharmacol. 2020 Oct;54:72-81. doi: 10.1016/j.coph.2020.08.008. Epub 2020 Sep 18. PMID: 32956895; PMCID: PMC7500898.
: Cavalli G, Colafrancesco S, Emmi G, Imazio M, Lopalco G, Maggio MC, Sota J, Dinarello CA. Interleukin 1?: a comprehensive review on the role of IL-1? in the pathogenesis and treatment of autoimmune and inflammatory diseases. Autoimmun Rev. 2021 Mar;20(3):102763. doi: 10.1016/j.autrev.2021.102763. Epub 2021 Jan 20. PMID: 33482337.
: Taffarel P, Jorro Barón F, Rodríguez AP, Widmer J, Meregallia C. Multisystem inflammatory syndrome in children related to COVID-19: An update regarding the presentation of two critically ill patients. Arch Argent Pediatr. 2021 Feb;119(1):e26-e35. English, Spanish. doi: 10.5546/aap.2021.eng.e26. PMID: 33458987.
: Ahmed S, Zimba O, Gasparyan AY. COVID-19 and the clinical course of rheumatic manifestations. Clin Rheumatol. 2021 Jul;40(7):2611-2619. doi: 10.1007/s10067-021-05691-x. Epub 2021 Mar 17. PMID: 33733315; PMCID: PMC7968918.
: Halepas S, Lee KC, Myers A, Yoon RK, Chung W, Peters SM. Oral manifestations of COVID-2019-related multisystem inflammatory syndrome in children: a review of 47 pediatric patients. J Am Dent Assoc. 2021 Mar;152(3):202-208. doi: 10.1016/j.adaj.2020.11.014. Epub 2020 Dec 9. PMID: 33632409; PMCID: PMC7832615.
: Dotan A, Muller S, Kanduc D, David P, Halpert G, Shoenfeld Y. The SARS-CoV-2 as an instrumental trigger of autoimmunity. Autoimmun Rev. 2021 Apr;20(4):102792. doi: 10.1016/j.autrev.2021.102792. Epub 2021 Feb 19. PMID: 33610751; PMCID: PMC7892316.
: Wang CJ, Worswick S. Cutaneous manifestations of COVID-19. Dermatol Online J. 2021 Jan 15;27(1):13030/qt2m54r7nv. PMID: 33560783.
: Silva Andrade B, Siqueira S, de Assis Soares WR, de Souza Rangel F, Santos NO, Dos Santos Freitas A, Ribeiro da Silveira P, Tiwari S, Alzahrani KJ, Góes- Neto A, Azevedo V, Ghosh P, Barh D. Long-COVID and Post-COVID Health Complications: Na Up-to-Date Review on Clinical Conditions and Their Possible Molecular Mechanisms. Viruses. 2021 Apr 18;13(4):700. doi: 10.3390/v13040700. PMID: 33919537; PMCID: PMC8072585.
: Marino A, Varisco T, Quattrocchi G, Amoroso A, Beltrami D, Venturiello S, Ripamonti A, Villa A, Andreotti M, Ciuffreda M, Cimaz R. Children with Kawasaki disease or Kawasaki-like syndrome (MIS-C/PIMS) at the time of COVID-19: are they all the same? Case series and literature review. Reumatismo. 2021 Apr 19;73(1):48-53. doi: 10.4081/reumatismo.2021.1331. PMID: 33874647.
: Fang Y, Aravamudan VM, Sridharan GK, Mehta KK, Sekhar R, Senguttuvan NB, Venkatachalam I, Abid MB. Kawasaki like illness due to COVID-19: a review of the literature. J Infect Dev Ctries. 2021 May 31;15(5):630-638. doi: 10.3855/jidc.14185. PMID: 34106885.
: Liu BM, Martins TB, Peterson LK, Hill HR. Clinical significance of measuring serum cytokine levels as inflammatory biomarkers in adult and pediatric COVID-19 cases: A review. Cytokine. 2021 Jun;142:155478. doi: 10.1016/j.cyto.2021.155478. Epub 2021 Feb 23. PMID: 33667962; PMCID: PMC7901304.
: Toraih EA, Hussein MH, Elshazli RM, Kline A, Munshi R, Sultana N, Taghavi S, Killackey M, Duchesne J, Fawzy MS, Kandil E. Multisystem inflammatory syndrome in pediatric COVID-19 patients: a meta-analysis. World J Pediatr. 2021 Apr;17(2):141-151. doi: 10.1007/s12519-021-00419-y. Epub 2021 Feb 20. PMID: 33608839; PMCID: PMC7895741.
: Verrotti A, Mazzocchetti C, Iannetti P. Definitive pathognomonic signs and symptoms of paediatric neurological COVID-19 are still emerging. Acta Paediatr. 2021 Jun;110(6):1774-1777. doi: 10.1111/apa.15827. Epub 2021 Mar 21. PMID: 33641209; PMCID: PMC8013208.
: Larenas-Linnemann D, Luna-Pech J, Navarrete-Rodríguez EM, Rodríguez-Pérez N, Arias-Cruz A, Blandón-Vijil MV, Del Rio-Navarro BE, Estrada-Cardona A, Onuma- Takane E, Pozo-Beltrán CF, Valencia-Herrera AM, Ortiz-Aldana FI, Toledo-Bahena ME. Cutaneous Manifestations Related to COVID-19 Immune Dysregulation in the Pediatric Age Group. Curr Allergy Asthma Rep. 2021 Feb 25;21(2):13. doi: 10.1007/s11882-020-00986-6. PMID: 33630167; PMCID: PMC7905763.
: Banday AZ, Arul A, Vignesh P, Singh MP, Goyal K, Singh S. Kawasaki disease and influenza-new lessons from old associations. Clin Rheumatol. 2021 Jul;40(7):2991-2999. doi: 10.1007/s10067-020-05534-1. Epub 2021 Jan 2. PMID: 33387094; PMCID: PMC7778392.
: Vahey GM, Marshall KE, McDonald E, Martin SW, Tate JE, Midgley CM, Killerby ME, Kawasaki B, Herlihy RK, Alden NB, Staples JE; Colorado Investigation Team2. Symptom Profiles and Progression in Hospitalized and Nonhospitalized Patients with Coronavirus Disease, Colorado, USA, 2020. Emerg Infect Dis. 2021 Feb;27(2):385-395. doi: 10.3201/eid2702.203729. PMID: 33496225; PMCID: PMC7853576.
: Martelli Júnior H, Machado RA, Martelli DRB, Barbosa MC, Bonan PRF, Coletta RD. Potential link between SARS-CoV-2 and Kawasaki disease: importance of dentists for the diagnosis. Braz Oral Res. 2021 Mar 12;35:e047. doi: 10.1590/1807-3107bor-2021.vol35.0047. PMID: 33729297.
: Elizabeth Whittaker; Alasdair Bamford; Julia Kenny; et al. Clinical Characteristics of 58 Children With a Pediatric Inflammatory Multisystem Syndrome Temporally Associated With SARS-CoV-2. JAMA. 2020;324(3):259-269. doi:10.1001/jama.2020.10369
: Mercier JC, Ouldali N, Melki I, Basmaci R, Levy M, Titomanlio L, Beyler C, Meinzer U. Severe acute respiratory syndrome coronavirus 2-related multisystem inflammatory syndrome in children mimicking Kawasaki disease. Arch Cardiovasc Dis. 2021 May;114(5):426-433. doi: 10.1016/j.acvd.2021.04.005. Epub 2021 May 24. PMID: 34052147; PMCID: PMC8141693.
: Mavrogeni SI, Kolovou G, Tsirimpis V, Kafetzis D, Tsolas G, Fotis L. The importance of heart and brain imaging in children and adolescents with Multisystem Inflammatory Syndrome in Children (MIS-C). Rheumatol Int. 2021 Jun;41(6):1037-1044. doi: 10.1007/s00296-021-04845-z. Epub 2021 Apr 17. PMID: 33864498; PMCID: PMC8052538.
: Feketea G, Vlacha V, Bocsan IC, Vassilopoulou E, Stanciu LA, Zdrenghea M. Vitamin D in Corona Virus Disease 2019 (COVID-19) Related Multisystem Inflammatory Syndrome in Children (MIS-C). Front Immunol. 2021 Mar 8;12:648546. doi: 10.3389/fimmu.2021.648546. PMID: 33763085; PMCID: PMC7982656.
: Lacina L, Brábek J, Fingerhutová Š, Zeman J, Smetana K Jr. Pediatric Inflammatory Multisystem Syndrome (PIMS) - Potential role for cytokines such Is IL-6. Physiol Res. 2021 Apr 30;70(2):153-159. doi: 10.33549/physiolres.934673. PMID: 33992044.
: Sancho-Shimizu V, Brodin P, Cobat A, Biggs CM, Toubiana J, Lucas CL, Henrickson SE, Belot A; MIS-C@CHGE, Tangye SG, Milner JD, Levin M, Abel L, Bogunovic D, Casanova JL, Zhang SY. SARS-CoV-2-related MIS-C: A key to the viral and genetic causes of Kawasaki disease? J Exp Med. 2021 Jun 7;218(6):e20210446. doi: 10.1084/jem.20210446. PMID: 33904890; PMCID: PMC8080850.
: She J, Liu L, Liu W. COVID-19 epidemic: Disease characteristics in children. J Med Virol. 2020 Jul;92(7):747-754. doi: 10.1002/jmv.25807. Epub 2020 Apr 15. PMID: 32232980; PMCID: PMC7228385.
: Campos LR, Cardoso TM, Martinez JCFF, Almeida RG, Silva RM, Fonseca AR, et al. Síndrome inflamatória multissistêmica pediátrica (MIS-C) temporariamente associada ao SARS-CoV-2. Resid Pediatr. 2020;10(2):1-6 DOI: 10.25060/residpediatr-2020.v10n2-348.
: Mary Beth F Son, MD; Kevin Friedman, MD. COVID-19: Multisystem inflammatory syndrome in children (MIS-C) clinical features, evaluation, and diagnosis. Uptodate, 2021.
: David E Wesson, MD; Mary L Brandt, MD. Acute appendicitis in children: Clinical manifestations and diagnosis. Uptodate, 2021.
: Deborah M Levy, MD, MS, FRCPC. Childhood-onset systemic lupus erythematosus (SLE): Clinical manifestations and diagnosis. Uptodate, 2021.


