Caloric restriction benefits on cardiorespiratory fitness and muscle strength with and without exercise training in humans: a systematic review and meta-analysis / Benefícios da restrição calórica na aptidão cardiorrespiratória e força muscular com e sem treino de exercício em humanos: uma revisão sistemática e meta-análise

Authors

  • Manoel Pereira da Silva
  • Natalia Salvatierra Lima
  • Kellen Cristina da Cruz Rodrigues
  • Guilherme Francisco Peruca
  • Amanda Veiga Sardeli

DOI:

https://doi.org/10.34119/bjhrv4n4-122

Keywords:

Dieta de Baixa Caloria, Teste de Esforço, Saúde, Desempenho, Aptidão física.

Abstract

Objetivo: Identificar os verdadeiros efeitos da restrição calórica (RC) sobre o consumo máximo de oxigênio (VO2máx) relativo e absoluto e força muscular. Métodos: Uma revisão sistemática foi conduzida em 5 bancos de dados, até novembro de 2019. Vinte e oito ensaios controlados foram incluídos nas meta-análises comparando RC sozinho vs. Dieta padrão (RC vs. controle) ou comparando RC mais treinamento físico vs. treinamento de exercício sozinho (RC + EX vs. EX) sobre o VO2máx e a força muscular. Resultados: RC + EX teve um efeito positivo para o VO2máx relativo (1,13 [0,49; 1,78]ml/kg/min, p <0,001), mas não teve nenhum efeito sobre a força muscular relativa (0,41 [-0,28; 1,09], p = 0,25) quando comparados ao EX. RC aumentou significativamente o VO2máx relativo (2,08 [0,90; 3,27]ml/kg/min, p <0,001) e a força relativa (0,47 [0,35; 0,59)], p <0,001), em comparação com dieta padrão. A análise complementar confirmou reduções significativas na massa corporal total, massa gorda e massa muscular entre todos os subgrupos, como esperado. O VO2máx absoluto e a força não foram melhorados por RC + EX ou RC quando comparados a EX e controle, respectivamente. Conclusão: A RC sozinha melhora significativamente o VO2máx relativo e a força muscular em indivíduos fisicamente não ativos.

 

References

Fontana L, Partridge L. Promoting health and longevity through diet: From model organisms to humans. Cell. 2015; 161(1):106–18. doi:10.1016/j.cell.2015.02.020.

Mitchell SJ, Madrigal-Matute J, Scheibye-Knudsen M, Fang E, Aon M, González-Reyes JA, et al. Effects of Sex, Strain, and Energy Intake on Hallmarks of Aging in Mice. Cell Metab. 2016; 23(6):1093–112. doi:10.1016/j.cmet.2016.05.027.

Balasubramanian P, Howell PR, Anderson RM. Aging and Caloric Restriction Research: A Biological Perspective With Translational Potential. EBioMedicine. 2017; 21: 37–44. doi:10.1016/j.ebiom.2017.06.015.

Most J, Tosti V, Redman LM, Fontana L. Calorie restriction in humans: An update. Ageing Research Reviews. 2017; 39: 36–45. doi:10.1016/j.arr.2016.08.005.

Ott B, Skurk T, Hastreiter L, Lagkouvardos I, Fischer S, Büttner J, et al. Effect of caloric restriction on gut permeability, inflammation markers, and fecal microbiota in obese women. Sci Rep. 2017; 7(1): 1-10. doi:10.1038/s41598-017-12109-9.

Brestoff JR, Artis D. Immune regulation of metabolic homeostasis in health and disease. Cell. 2015; 161(1): 146–60. doi:10.1016/j.cell.2015.02.022.

Yamada Y, Kemnitz JW, Weindruch R, Anderson RM, Schoeller DA, Colman RJ. Caloric Restriction and Healthy Life Span: Frail Phenotype of Nonhuman Primates in the Wisconsin National Primate Research Center Caloric Restriction Study. J Gerontol A. 2018; 73(3): 273–8. doi:10.1093/gerona/glx059.

Nicklas BJ, Brinkley TE, Houston DK, Lyles MF, Hugenschmidt CE, Beavers KM, et al. Effects of Caloric Restriction on Cardiorespiratory Fitness, Fatigue, and Disability Responses to Aerobic Exercise in Older Adults with Obesity: A Randomized Controlled Trial. Journals Gerontol A. 2019; 74(7): 1084–90. doi:10.1093/gerona/gly159.

Larson-Meyer DE, Redman L, Heilbronn LK, Martin CK, Ravussin E. Caloric restriction with or without exercise: the fitness versus fatness debate. Med Sci Sports Exerc. 2010; 42(1): 152–9. doi:10.1249/MSS.0b013e3181ad7f17.

Nicklas BJ, Chmelo E, Delbono O, Carr JJ, Lyles MF, Marsh AP. Effects of resistance training with and without caloric restriction on physical function and mobility in overweight and obese older adults: a randomized controlled trial. Am J Clin Nutr. 2015; 101(5): 991–9. doi:10.3945/ajcn.114.105270.

Velthuis-te Wierik EJ, Hoogzaad L V, van den Berg H, Schaafsma G. Effects of moderate energy restriction on physical performance and substrate utilization in non-obese men. Int J Sports Med. 1994; 15(8): 478–84. doi:10.1055/s-2007-1021091.

Naharudin MN Bin, Yusof A. The effect of 10 days of intermittent fasting on Wingate anaerobic power and prolonged high-intensity time-to-exhaustion cycling performance. Eur J Sport Sci. 2018; 18(5): 667–76. doi:10.1080/17461391.2018.1438520.

Racette SB, Rochon J, Uhrich ML, Villareal DT, DAS SK, Fontana L, et al. Effects of Two Years of Calorie Restriction on Aerobic Capacity and Muscle Strength. Med Sci Sports Exerc. 2017; 49(11): 2240–9. doi:10.1249/MSS.0000000000001353.

Garber CE, Blissmer B, Deschenes MR, Franklin BA, Lamonte MJ, Lee I-M, et al. American College of Sports Medicine position stand. Quantity and quality of exercise for developing and maintaining cardiorespiratory, musculoskeletal, and neuromotor fitness in apparently healthy adults: guidance for prescribing exercise. Med Sci Sports Exerc. 2011; 43:1334–59. doi:10.1249/MSS.0b013e318213fefb.

Moher D, Liberati A, Tetzlaff J, Altman DG, Altman D, Antes G, et al. Preferred reporting items for systematic reviews and meta-analyses: The PRISMA statement. PLoS Medicine. 2009; 339: b2535. doi:10.1371/journal.pmed.1000097.

Ghroubi S, Elleuch H, Kaffel N, Echikh T, Abid M, Elleuch MH. [Contribution of exercise and diet in the management of knee osteoarthritis in the obese]. Ann Readapt Med Phys. 2008; 51: 663–70. doi:10.1016/j.annrmp.2008.07.035.

Dhahbi JM, Kim HJ, Mote PL, Beaver RJ, Spindler SR. Temporal linkage between the phenotypic and genomic responses to caloric restriction. Proc Natl Acad Sci U S A. 2004; 101: 5524–9. doi:10.1073/pnas.0305300101.

Artioli GG, Iglesias RT, Franchini E, Gualano B, Kashiwagura DB, Solis MY, et al. Rapid weight loss followed by recovery time does not affect judo-related performance. J Sports Sci. 2010; 28(1): 21–32. doi:10.1080/02640410903428574.

Naharudin MN Bin, Yusof A. The effect of 10 days of intermittent fasting on Wingate anaerobic power and prolonged high-intensity time-to-exhaustion cycling performance. Eur J Sport Sci. 2018; 18(5): 667–76. doi:10.1080/17461391.2018.1438520.

Booth CK, Coad RA, Forbes-Ewan CH, Thomson GF, Niro PJ. The Physiological and Psychological Effects of Combat Ration Feeding during a 12-Day Training Exercise in the Tropics. Mil Med. 2003; 168(1): 63–70. doi:10.1093/milmed/168.1.63.

Imayama I, Alfano CM, Kong A, Foster-Schubert KE, Bain CE, Xiao L, et al. Dietary weight loss and exercise interventions effects on quality of life in overweight/obese postmenopausal women: a randomized controlled trial. Int J Behav Nutr Phys Act. 2011; 8(1): 1-12. doi:10.1186/1479-5868-8-118.

Vissers D, Verrijken A, Mertens I, Van Gils C, Van de Sompel A, Truijen S, et al. Effect of long-term whole body vibration training on visceral adipose tissue: a preliminary report. Obes Facts. 2010; 3: 93–100. doi:10.1159/000301785.

Mihalko SL, Cox P, Beavers DP, Miller GD, Nicklas BJ, Lyles M, et al. Effect of intensive diet and exercise on self-efficacy in overweight and obese adults with knee osteoarthritis: The IDEA randomized clinical trial. Transl Behav Med. 2019; 9(2): 227–35. doi:10.1093/tbm/iby037.

Maher CG, Sherrington C, Herbert RD, Moseley AM, Elkins M. Reliability of the PEDro scale for rating quality of randomized controlled trials. Phys Ther. 2003; 83(8): 713–21. doi.org/10.1093/ptj/83.8.713.

Guyatt GH, Oxman AD, Vist GE, Kunz R, Falck-Ytter Y, Alonso-Coello P, et al. GRADE: An emerging consensus on rating quality of evidence and strength of recommendations. BMJ. 2008; 336(7650): 924-6. doi:10.1136/bmj.39489.470347.AD.

Jiménez-Pavón D, Lavie CJ, Blair SN. The role of cardiorespiratory fitness on the risk of sudden cardiac death at the population level: A systematic review and meta-analysis of the available evidence. Prog Cardiovasc Dis. 2019; 62(3): 279–87. doi:10.1016/j.pcad.2019.05.003.

Anagnostou M-E, Hepple RT. Mitochondrial Mechanisms of Neuromuscular Junction Degeneration with Aging. Cells. 2020; 9(1): 197. doi:10.3390/cells9010197.

Angulo J, El Assar M, Rodríguez-Mañas L. Frailty and sarcopenia as the basis for the phenotypic manifestation of chronic diseases in older adults. Molecular Aspects of Medicine. 2016; 50: 1–32. doi:10.1016/j.mam.2016.06.001.

Colman RJ, Beasley TM, Kemnitz JW, Johnson SC, Weindruch R, Anderson RM. Caloric restriction reduces age-related and all-cause mortality in rhesus monkeys. Nat Commun. 2014; 5(1): 1–5. doi:10.1038/ncomms4557.

Il’yasova D, Fontana L, Bhapkar M, Pieper CF, Spasojevic I, Redman LM, et al. Effects of 2 years of caloric restriction on oxidative status assessed by urinary F2-isoprostanes: The CALERIE 2 randomized clinical trial. Aging Cell. 2018; 17. doi:10.1111/acel.12719.

Meydani SN, Das SK, Pieper CF, Lewis MR, Klein S, Dixit VD, et al. Long-term moderate calorie restriction inhibits inflammation without impairing cell-mediated immunity: A randomized controlled trial in non-obese humans. Aging (Albany NY). 2016; 8(7): 1416–31. doi:10.18632/aging.100994.

Yang L, Licastro D, Cava E, Veronese N, Spelta F, Rizza W, et al. Long-Term Calorie Restriction Enhances Cellular Quality-Control Processes in Human Skeletal Muscle. Cell Rep. 2016; 14(3): 422–8. doi:10.1016/j.celrep.2015.12.042.

Powers SK, Smuder AJ, Judge AR. Oxidative stress and disuse muscle atrophy: Cause or consequence?. Curr Opin Clin Nutr Metab Care. 2012; 15(3) 240–5. doi:10.1097/MCO.0b013e328352b4c2.

Brown-Borg HM, Rakoczy S. Metabolic adaptations to short-term every-other-day feeding in long-living Ames dwarf mice. Exp Gerontol. 2013; 48(9): 905–19. doi:10.1016/j.exger.2013.06.009.

Sardeli A V, Komatsu TR, Mori MA, Gáspari AF, Chacon-Mikahil MPT. Resistance Training Prevents Muscle Loss Induced by Caloric Restriction in Obese Elderly Individuals: A Systematic Review and Meta-Analysis. Nutrients. 2018; 10(4): 423. doi:10.3390/nu10040423.

Amati F, Dubé JJ, Shay C, Goodpaster BH. Separate and combined effects of exercise training and weight loss on exercise efficiency and substrate oxidation. J Appl Physiol. 2008; 105:825–31. doi:10.1152/japplphysiol.90384.2008.

Armamento-Villareal R, Aguirre L, Napoli N, Shah K, Hilton T, Sinacore DR, et al. Changes in thigh muscle volume predict bone mineral density response to lifestyle therapy in frail, obese older adults. Osteoporos Int. 2014; 25(2): 551–8. doi:10.1007/s00198-013-2450-2.

Bouchard DR, Soucy L, Senechal M, Dionne IJ, Brochu M. Impact of resistance training with or without caloric restriction on physical capacity in obese older women. Menopause. 2009; 16(1): 66–72. doi:10.1097/gme.0b013e31817dacf7.

Cox KL, Burke V, Morton AR, Beilin LJ, Puddey IB. The independent and combined effects of 16 weeks of vigorous exercise and energy restriction on body mass and composition in free-living overweight men--a randomized controlled trial. Metabolism. 2003; 52(1): 107–15. doi:10.1053/meta.2003.50017.

Davis JN, Tung A, Chak SS, Ventura EE, Byrd-Williams CE, Alexander KE, et al. Aerobic and strength training reduces adiposity in overweight latina adolescents. Med Sci Sports Exerc. 2009; 41(7): 1494–503. doi:10.1249/MSS.0b013e31819b6aea.

Dengel DR, Pratley RE, Hagberg JM, Rogus EM, Goldberg AP. Distinct effects of aerobic exercise training and weight loss on glucose homeostasis in obese sedentary men. J Appl Physiol. 1996; 81: 318–25. doi:10.1152/jappl.1996.81.1.318.

Elloumi M, Makni E, Ounis O Ben, Moalla W, Zbidi A, Zaoueli M, et al. Six-minute walking test and the assessment of cardiorespiratory responses during weight-loss programmes in obese children. Physiother Res Int. 2011; 16(1): 32–42. doi:10.1002/pri.470.

Figueroa A, Vicil F, Sanchez-Gonzalez MA, Wong A, Ormsbee MJ, Hooshmand S, et al. Effects of diet and/or low-intensity resistance exercise training on arterial stiffness, adiposity, and lean mass in obese postmenopausal women. Am J Hypertens. 2013; 26(3): 416–23. doi:10.1093/ajh/hps050.

García-Hermoso A, Saavedra JM, Escalante Y, Domínguez AM, Castro-Piñero J. Effects of an exercise program with or without a diet on physical fitness in obese boys: A three-year follow-up. Prog Nutr. 2018; 20(1): 94–103. doi:10.23751/pn.v20i1.5836.

Melanson KJ, Dell’Olio J, Carpenter MR, Angelopoulos TJ. Changes in multiple health outcomes at 12 and 24 weeks resulting from 12 weeks of exercise counseling with or without dietary counseling in obese adults. Nutrition. 2004; 20(10): 849–56. doi:10.1016/j.nut.2004.06.004.

Nordby P, Auerbach PL, Rosenkilde M, Kristiansen L, Thomasen JR, Rygaard L, et al. Endurance training per se increases metabolic health in young, moderately overweight men. Obesity. 2012; 20(11): 2202–12. doi:10.1038/oby.2012.70.

Rosenkilde M, Rygaard L, Nordby P, Nielsen LB, Stallknecht B. Exercise and weight loss effects on cardiovascular risk factors in overweight men. J Appl Physiol. 2018; 125(3): 901–8. doi:10.1152/japplphysiol.01092.2017.

Villareal DT, Chode S, Parimi N, Sinacore DR, Hilton T, Armamento-Villareal R, et al. Weight loss, exercise, or both and physical function in obese older adults. N Engl J Med. 2011; 364(13): 1218–29. doi:10.1056/NEJMoa1008234.

Ross R, Janssen I, Dawson J, Kungl A-M, Kuk JL, Wong SL, et al. Exercise-induced reduction in obesity and insulin resistance in women: a randomized controlled trial. Obes Res. 2004; 12(5): 789–98. doi:10.1038/oby.2004.95.

Ribeiro JLC, Silva AF, Mendes GS, Aguiar LL, Oribe LA. Intermittent fasting is better than simple caloric restriction? A review. Braz. J. Hea. Rev. 2020; 3 (4): 9340-9343. doi: :10.34119/bjhrv3n4-171.

Published

07/29/2021

How to Cite

DA SILVA, M. P.; LIMA, N. S.; RODRIGUES, K. C. da C.; PERUCA, G. F.; SARDELI, A. V. Caloric restriction benefits on cardiorespiratory fitness and muscle strength with and without exercise training in humans: a systematic review and meta-analysis / Benefícios da restrição calórica na aptidão cardiorrespiratória e força muscular com e sem treino de exercício em humanos: uma revisão sistemática e meta-análise. Brazilian Journal of Health Review, [S. l.], v. 4, n. 4, p. 15928–15951, 2021. DOI: 10.34119/bjhrv4n4-122. Disponível em: https://ojs.brazilianjournals.com.br/ojs/index.php/BJHR/article/view/33592. Acesso em: 19 oct. 2026.

Issue

Section

Original Papers