Lactobacillus acidophillus: efeito funcional como adjuvante na terapia oncológica e prevenção ao desenvolvimento de Câncer Colorretal/ Lactobacillus acidophillus: functional effect as an adjuvant in oncological therapy and prevention of the development of Colorectal Cancer
DOI:
https://doi.org/10.34119/bjhrv4n1-311Keywords:
Probióticos, Antioxidantes, Neoplasias Colorretais.Abstract
Lactobacillus acidophilus é uma espécie de bactérias ácido-lática com atividade probiótica reconhecida. Diversos estudos têm demonstrado atividade funcional das cepas bacterianas desse gênero, com relevância de efeitos antioxidantes em doenças como o câncer colorretal. O objetivo do trabalho é revisar os efeitos funcionais relacionados com a administração de L. acidophilus como adjuvante na terapia oncológica e como prevenção ao desenvolvimento de câncer colorretal. Foram consultadas bases de dados como Google Acadêmico, Pubmed, Scielo, Scopus e Web of Science selecionando artigos que apresentavam atividade de Lactobacillus acidophilus em estudos in vitro, em animais e em seres humanos com câncer colorretal. Os estudos in vitro realizados em linhagens celulares e em animais demonstraram alguns mecanismos de ação das cepas e de frações bacterianas, como inibição da proliferação celular, supressão de fatores pró-carcinogênicos, melhoria dos níveis de sistemas antioxidantes e melhora da homeostase intestinal. Os estudos em seres humanos feitos exclusivamente contendo L. acidophilus em câncer colorretal são poucos, estando geralmente associado à outros probióticos, mas demonstram efeitos interessantes na minimização de complicações pós operatórias e melhora da integridade da barreira intestinal. Esses resultados sugerem a necessidade de mais estudos com L. acidophilus para verificar seus mecanismos a nível celular e molecular para posteriormente, ser possível realizar estudos em seres humanos com a bactéria isolada.
References
WEST, NP, HORN, PL, BARRETT, S, WARREN, HS, LEHTINEN, MJ, KOERBIN, G, et al. Supplementation with a single and double strain probiotic on the innate immune system for respiratory illness. e-SPEN J. 2014; 9(n): e178-184.
GHANY, KAE, HAMOUDA, R, ELHAFEZ, EA, MAHROUS, H, SALEM-BEKHIT, M. A potential role of Lactobacillus acidophilus LA1 and its exopolyssaccharides on cancer cells in male albino mice. Biotechnol Biotechnol Equipment. 2015; 29 (n): 977-983.
VERMA, A, SHUKLA, G. Synbiotic (Lactobacillus rhamnosus+Lactobacillus acidophilus+inulin) attenuatues oxidative stress and colonic damage in 1,2 dimetilhidrazine dihydrochloride-induced colon carcinogenesis in Sprague-Dawley rats: a long-term study. Eur J Cancer Prev. 2014; 23 (6): 550-559.
OLIVEIRA, TR, FORTES, RC. Hábitos alimentares de pacientes com câncer colorretal. J Health Sci. Inst. 2013; 31 (1): 59-64.
FLOROU-PANERI, P, CHRISTAKI, E, BONOS, E. Lactic Acid Bacteria as Source of Functional Ingredients. In: Kongo, JM. Lactic Acid Bacteria – R & D for Food, Health and Livestock Purposes. London: InTech, 2013 [citado 2013 janeiro 30]. Disponível em: http://www.intechopen.com/books/lactic-acid-bacteria-r-d-for-food-health-and-livestock-purposes/lactic-acid-bacteria-as-source-of-functional-ingredients.
HARUTOSHI, T.. Exopolyssaccharides of Lactic Acid Bacteria for Food and Colon health Applications. Lactic Acid Bacteria – R & D for Food, Health and Livestock Purposes. London: InTech, 2013 [citado 2013 janeiro 30]. Disponível em: http://www.intechopen.com/books/lactic-acid-bacteria-r-d-for-food-health-and-livestock-purposes/exopolysaccharides-of-lactic-acid-bacteria-for-food-and-colon-health-applications.
VANDENPLAS, Y, HUYS, G, DAUBE, G. Probiotics: an update. J Pediatr. 2015; 91 (1): 6-21.
HUANG, R, WANG, K, HU, J. Effect of probiotics on depression: a systematic review and meta-analysis of randomized controlled trials. Nutrients. 2016; 8 (8): 483-494.
HIBBERD, AA, LYRA, A, OUWEHAND, AC, ROLNY, P, LINDEGREN, H, CEDGÄRD, L, et al. Intestinal microbiota is altered in patients with colon cancer and modified by probiotic intervention. BMJ Open Gastroenterol. 2017 [citado 2017 maio 22]; 4:e000145). http://doi: 10.1136 / bmjgast-2017-000145.
MENG, J, ZHANG, Q,X, LU, R,R. Surface layer protein from Lactobcillus acidophilus NCFM inhibit intestinal pathogen-induced apoptosis in HT-29 cells. Int J Biol Macromolecules. 2017; 96: 766-774.
PEPOYAN, A, BALAYAN, M, MANVELYAN, A, GALSTYAN, L, PEPOYAN, S, PETROSYAN, S. et al. Probiotic Lactobacillus acidophilus Strain INMIA 9602 Er 317/402 administration reduces the numbers of Candida albicans and abundance of Enterobacteria in gut microbiota of familial mediterranean fever patients. Front Immunol. 2018; 9: 1426, 11 p.
VEMURI, R, SHINDE, T, SHASTRI, MD, PERERA, AP, TRISTRAM, S, MARTONI, CJ. et al. A human origin strain Lactobacillus acidophilus DDS-1 exhibits superior in vitro probiotic efficacy in comparison to plant or dairy origin probiotics. Int J Med Sci. 2018; 15 (9): 840-848.
GONÇALVES, P, MARTEL, F. Regulation of colonic epithelial butyrate transport: Focus on colorectal cancer. Porto Biomedical Journal. 2016; 1 (3): 83-91.
SOLTAN DALLAL, MM, MOJARRAD, M, BAGHBANI, F, RAOOFIAN, R, MARDANEH, J, SALEHIPOUR, Z. Effects of probiotic Lactobacillus acidophilus and Lactobacillus casei on colorectal tumor cells activity (CaCo-2). Arch Iran Med. 2015; 18 (3): 167-172.
LIU, H, WU, H, BILEGSAIKHAN, E, LU, EX, SHEN, X, LIU, T. Diferential expression of intestinal microbiota in colorectal cancer compared with healthy controls: a systematic review and meta-analysis. Int J Clin Exp Med.2016; 9 (6): 10923-10930.
REIS, SA, CONCEIÇÃO, LL, SIQUEIRA, NP, ROSA, DD, SILVA, LL, PELUZIO, MCG. Review of mechanisms of probiotic actions in the prevention of colorectal cancer. Nutr Res. 2017; 37: 1-19.
MENDONÇA, PS, CARIOCA, AAF, MAIA, FMM. Interações entre estresse oxidativo, terapia utilizada e estadiamento em pacientes com câncer colorretal. Cancer Br. 2014; 60 (2): 129-134.
DEEPAK, V, RAMACHANDRAN, S, BALAHMAR, RM, PANDIAN, SRK, SIVASUBRAMANIAM, SD, NELLAIAH, H, et al. In vitro evaluation of anticancer properties of exopolysaccharides from Lactobacillus acidophilus in colon câncer cell lines. In Vitro Cell Dev Biol Anim. 2016; 52 (2): 163-173.
AGAH, S, ALIZADEH, AM, MOSAVI, M, RANJI, P, KHAVARI, DANESHVAR, H, et al. More protection of Lactobacillus acidophilus than Bifidobacterium bifidum probiotics on azoxymethane induced mouse colon cancer. Probiotics Antimicrob Proteins. 2018 [citado 2018 abril 22]. https://doi.org/10.1007/s12602-018-9425-8.
PATTEN, D.A.; LEIVERS, S.; CHADHA, M.J.; MAQSOOD, M.; HUMPHREYS, P.N.; LAWS, A.P.; COLLETT, A. (2014). The structure and immunomodulatory activity on intestinal epithelial cells of the EPSs isolated from Lactobacillus helveticus sp. Rosyjski and Lactobacillus acidophilus sp. 5e2. Carbohydr Res. 2014; 384: 119-127.
OLIVEIRA, FM, BARBOSA JÚNIOR, F, JORDÃO JÚNIOR, AA, FOSS, NT, NAVARRO, AM, FRADE, MAC. Estresse oxidativo e micronutrientes na hanseníase. Rev Nutr. 2015; 28 (4): 349-357.
VALENTINI, L, PINTO, A, BOURDEL-MARCHASSON, I, OSTAN, R, BRIGIDI, P, TURRONI, S, et al. (2015). Impact of personalized diet and probiotic supplementation on inflammation, nutritional parameters and microbiota intestinal – The “RISTOMED project”: randomized controlled trial in healthy older people. Clin Nutr. 2015; 34 (4): 593-602.
GAO, Z, GUO, B, GAO, R, ZHU, Q, WU, W, QIN, H. Probiotics modify human intestinal mucosa-associated microbiota in patients with colorectal cancer. Mol Med Rep. 2015; 12 (n) 6119-6127.
LIU, Z, LI, C, HUANG, M, TONG, C, ZHANG, X, WANG, L, et al. Positive regulatory effects of perioperative probiotic treatment on postoperative liver complications after colorectal liver metastases surgery: a double center and double-blind randomized clinical trial. BMC Gastroenterol. 2015; 15 (34): 13 p.
SANCHEZ, MT, RUIZ, MA, MORALES, ME. Microorganismos probioticos y salud. Ars Pharm. 2015; 56 (1): 45-59.
FLESCH, AT, TONIAL, ST, CONTU, PC, DAMIN, DC. A administração perioperatória de simbióticos em pacientes com câncer colorretal diminui a incidência de infecções pós-operatórias: ensaio clínico randomizado duplo-cego. Rev Coo Bras Cir. 2017; 44 (6): 567-573.
LIU, Z, HUANG, M, ZHANG, X, WANG, L, HUANG, N, PENG, H, et al. The effects of perioperative probiotic treatment on serum zonulin concentration and subsequent postoporeative infectious complications after colorectal cancer surgery: a double-center and double-blind randomized clinical trial. Am J Clin Nutr. 2013; 97 (1): 117-126.
BULTMAN, SJ. The microbiome and its potential as a cancer preventive intervention. Semin Oncol. 2016; 43 (1): 97-106.
LEPINE, AFP, DE VOS, P. Synbiotic effects of the dietary fiber long-chain inulin and probiotic Lactobacillus acidophilus W37 can be caused by direct, synergistic stimulation of immune Toll-like receptors and dendritic cells. Mol Nutr Food Res. 2018 [citado 2018 junho 14]; 14:e1800251. https://doi.org/10.1002/mnfr.201800251
