Toxicological evaluation of Carthamus lanatus L (Carthame laineux) hydro-alcoholic extract in Wistar rats: acute oral toxic effects
DOI:
https://doi.org/10.34115/basrv8n2-015Keywords:
Carthamus lanatus L, hematological índices, biochemical parametersAbstract
Background: Despite the well-known phytotherapeutic properties of Carthamus lanatus L in traditional medicine, there is little evidence on its toxicity profile in hematological and biochemical parameters. Objective: This study was intended to evaluate the acute toxicity effect of Carthamus lanatus L. Methods: The toxicological impact of a hydroalcholic extract of Carthamus lanatus (HAECL) at 200, 400, and 800 mg/kg body weight on hematological indices in rats was assessed gradually at 24 hours after 1, 10, and 14 days. Results: We observed no significant difference in the consumption of food, body weight, or relative organ weights. Hematological and biochemical parameters revealed the non-adverse effects of prolonged oral consumption of Carthamus lanatus except for a slight increase but no significant increase in ASAT and ALAT and a no significant decrease in the percentage of basophils. Conclusions: These data imply that the extract has a non-hematotoxic potential. Overall, the impact of carthamus lanatus extract in this study shows that it is unlikely to be hematotoxic and might be a promising candidate in the treatment of coronary heart disease if taken at the levels tested.
References
ABDELKHALEK, Sara Taha, SHI, Jin-Hua, JIN, Mei-Xiang, et al.Classification of Phytochemicals in Plants with Herbal Value. In : Herbal Medicine Phytochemistry: Applications and Trends. Cham :Springer International Publishing, 2024. p. 1-39.
ADLER, Isabell K., FIEDLER, Daniela, et HARMS, Ute. About birds and bees, snails and trees: Children's ideas on animal and plant evolution. Science Education, 2024.
AKRAM, Melakhessou Mohamed, NAIMA, Benkiki, EDDINE, Marref Salah, et al. Anti-Inflammatory, Anti-pyretic and Acute Toxicity Effects of n-Butanol Extract of Atractylis flava Desf in Rats. Pharmacognosy Journal, 2018, vol. 10, no 4.
AMOATENG, Emmanuel Owusu, AMOATENG, Patrick, OSSEI, Paul Poku Sampene, et al. An acute and sub-acute toxicological assessment of Reissantia indica plant extract in male Sprague-Dawley rats: Hematological, serum biochemical and histopathology. Scientific African, 2024, vol. 23, p. e02089.
ARIYO, Oluwakemi O, AJAYI, Abayomi M, ATTAH, Francis A, et al. Acute and subacute toxicological evaluation of the ethanol leaf extract of Morus mesozygia stapf.(Moraceae) in rodents. Journal of Ethnopharmacology, 2024, vol. 328, p. 118112.
ARUNACHALAM, Karuppusamy, MATCHADO, Monica Steffi, DAMAZO, Amilcar Sabino, et al. Casearia sylvestris var. lingua (Càmbess.) Eichler leaves aqueous extract improves colon inflammation through mucogenic, antioxidant and anti-inflammatory actions in TNBS-induced IBD rats. Journal of Ethnopharmacology, 2024, p. 118393.
BABANDI, Abba, YUSSUFF, Yussuff Momohjimoh, YAKASAI, Hafeez Muhammad, et al. Determination of heavy metals contamination, risk prediction and antioxidant properties of anti-malarial herbal mixture sold in Kano state, Nigeria. Case Studies in Chemical and Environmental Engineering, 2024, vol. 9, p. 100576.
CHE, C.-T., GEORGE, V., IJINU, T. P., et al. Traditional medicine. In : Pharmacognosy. Academic Press, 2024. p. 11-28.
IZAH, Sylvester Chibueze, OGIDI, Odangowei Inetiminebi, OGWU, Matthew Chidozie, et al. Historical Perspectives and Overview of the Value of Herbal Medicine. In : Herbal Medicine Phytochemistry: Applications and Trends. Cham : Springer International Publishing, 2024. p. 3-35.
JACOB, Daniel Etim, IZAH, Sylvester Chibueze, NELSON, Imaobong Ufot, et al. Indigenous Knowledge and Phytochemistry: Deciphering the Healing Power of Herbal Medicine. In : Herbal Medicine Phytochemistry: Applications and Trends. Cham : Springer International Publishing, 2024. p. 1953-2005.
MARREF Salah Eddine, MELAKHESSOU, Mohamed Akram, BECHEKER Imene, et al. Acute Oral Toxicity, Anti-Inflammatory and Anti-pyretic Activities of Methanol Extract of Moringa oleifera LAM in Albino Rats. Afr.J.Bio.Sc. 6(13) (2024) 2432-2441. https://doi.org/10.33472/AFJBS.6.13.2024.2432-2441
MARREF, Salah Eddine, BENKIKI, Naima, MELAKHESSOU, Mohamed Akram, et al. Acute Toxicity, Anti-ulcer and Anti-inflammatory Effects of Methanol Extract of Gladiolus segetum in Rats. Pharmacognosy Journal, 2018, vol. 10, no 4.
MARREF, Salah Eddine, MELAKHESSOU, Mohamed Akram, BECHEKER, Imene, et al. Pharmacological Evaluation of Antidiabetic Capacity of Moringa oleifera LAM Leaves. Journal of Biobased Materials and Bioenergy, 2024, vol. 18, no 3, p. 404-409.
Melakhessou Mohamed Akram , Marref Salah Eddine , Becheker Imene . Potential Anti-İnflammatory and Apoptotic Effect of Carthamus Lanatus Extract in Human Leukemia Cell Line THP-1. Afr.J.Bio.Sc. 6(13) 2024,1448-1456 https://doi.org/10.33472/AFJBS.6.13.2024.1448-1456
MELAKHESSOU,MohamedAkram,BECHEKER, Imene, MARREF, Salah Eddine, et al. A Property-Response Approach to Evaluate Acute Toxicity Profile and Pharmacological Quality of Hydro-Alcoholic Extract of Walnut Root Bark Juglans Regia Linn. in Streptozotocin-Induced Diabetic Mode. Journal of Biobased Materials and Bioenergy, 2023, vol. 17, no 4, p. 451-459.
NG, Bobby G., FREEZE, Hudson H., HIMMELREICH, Nastassja, et al. Clinical and biochemical footprints of congenital disorders of glycosylation: Proposed nosology. Molecular Genetics and Metabolism, 2024, vol. 142, no 1, p. 108476.
OGIDI, Odangowei Inetiminebi et EMAIKWU, Ngozi Georgewill. Adoption and application of biotechnology in herbal medicine practices. In : Herbal medicine phytochemistry: Applications and trends. Cham : Springer International Publishing, 2024. p. 1601-1626.
PARIHAR, Niraj, BARVE, Kalyani, et BHATT, Lokesh Kumar. Clinical, ethical, and regulatory issues of botanicals. In : Phytopharmaceuticals and Herbal Drugs. Academic Press, 2023. p. 265-279.
SHARMA, Alok Nath, DEWANGAN, Hitesh Kumar, et UPADHYAY, Prabhat Kumar. Comprehensive review on herbal medicine: emphasis on current therapy and role of phytoconstituents for cancer treatment. Chemistry & biodiversity, 2024, vol. 21, no 3, p. e202301468.
