Baixa concentração de trans-resveratrol inibe o crescimento e formação de biofilme de Staphylococcus aureus UFPEDA 02
DOI:
https://doi.org/10.34115/basrv7n2-001Keywords:
ativos botânicos, patógenos prioritários da OMS, biofilme, coleção de culturas UFPEDAAbstract
Staphylococcus aureus é uma bactéria de preocupação global, classificada pela Organização Mundial da Saúde como um patógeno prioritário de nível alto e diferentes estratégias são empenhadas para reduzir os riscos de infecções. Este trabalho teve por objetivo avaliar a atividade do trans-resveratrol contra a linhagem de S. aureus UFPEDA 02. Foi realizada a determinação da Concentração Inibitória Mínima (CIM), Concentração Bactericida Mínima (CBM) e o Ensaio in vitro de formação do biofilme por 48 h. O trans-resveratrol demonstrou atividade na concentração de 2,5 µg/mL. Houve inibição do crescimento planctônico sem produzir efeito bactericida. O composto promoveu uma ação antibiofilme alta (cerca de 80%), com grau de inibição moderado. Em complemento não foram observadas células com capacidade de formar biofilme, visto que o ponto de corte do teste foi de 0,177. Como conclusão, o trans-resveratrol se mostrou promissor no combate ao crescimento de S. aureus UFPEDA 02.
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